Jason wilson @JSamWilson

BBSRC Discovery Fellow | #CryoEM 🔬 | Phages - Antimicrobials - Host Takeover | He/Him Joined August 2009

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Jason wilson @JSamWilson

7 months ago

Contact myself + Prof. Per Bullough for more info

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🚨 Funded PhD Opportunity - Cryo-EM & Structural Biology (Sheffield, UK) Study toxic bacteriophage proteins targeting drug-resistant Enterococcus. Training in cryo-EM, AlphaFold, protein biochemistry & infection biology. 🔗 Apply by 7 Jan 2026 More info: yorkshirebiosciencedtp.ac.uk

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Paul CM Fogg @PCMFogg

2 years ago

We have a fascinating preprint just out, revealing the widespread packaging of bacterial genomic DNA into capsids in the human gut:bit.ly/3B2ajza. Major denizens of the #microbiome implicated with broad potential impact on bacterial evolution and horizontal gene transfer

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Jason wilson @JSamWilson

2 years ago

@thesteinegger @NAR_Open Really nice resource, congrats. Is there a way to search the database based on the phage host or function description e.g. all E.coli phage hypothetical proteins?

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Andrey Shkoporov @AShkoporov

2 years ago

Check out our new preprint (biorxiv.org/content/10.110…) describing widespread bacterial DNA packaging by #bacteriophages and gene transfer agents (GTA) in the human gut #microbiome. Many thanks to @PCMFogg, @JSamWilson, Pavol Bardy, and @colinhillucc for collaborating with us.

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GAMA Miguel Angel 🐦‍⬛🔑 @miangoar

2 years ago

🧵one of my favorite tools: Foldseek (1/7) We have traced the evo of species by comparing their proteins. We use models that assign a %similarity between seqs and confidently infer that 2 proteins are homologous if share ≥25% SeqSim. But what happens when it’s less than this?

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Jason wilson @JSamWilson

2 years ago

Very happy to have played a part in this study, great to see it out in preprint form. biorxiv.org/content/10.110…

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Gatsogiannis Lab @GatsogiannisLab

2 years ago

"Ever wondered how α-latrotoxin, the black widow spider's 🕷️ neurotoxin, turns into a cation-selective channel? Check out our latest manuscript! rdcu.be/dWez3 @NatureComms #Neuroscience #Toxin #cryoEM @sfb1348 @uni_muenster

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Jan Binovsky @JanyBinovsky

2 years ago

🚀Announcing my first (co)first-author manuscript 🚀 "Cell attachment and tail contraction of S. aureus phage phi812" 🔗bit.ly/Phi812 Check out the 🧵 to explore the structural details of phage interaction with Gram+ bacteria🤯 #PhageTherapy #Research #PhDlife 1/11

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Jason wilson @JSamWilson

2 years ago

@ScienceShef A huge thank you also to everyone who supported me during my application 🙏⭐️

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Jason wilson @JSamWilson

2 years ago

Excited to get started as a BBSRC Discovery Fellow at @ScienceShef in October. I'll be looking to understand how bacteriophages hijack their hosts and how we can exploit that understanding towards new antimicrobials 🔬🦠

Biotechnology and Biological Sciences Research @BBSRC

2 years ago

Meet the 15 new BBSRC Discovery Fellows who are receiving a collective £6m of investment for early-career independent research. The fellowship scheme, now in its 10th year, supports promising researchers who aspire to secure the future of biosciences. orlo.uk/c0ih2

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Jess Buddle @BuddleJess

2 years ago

✨️ It's been a long time coming ✨️ journals.plos.org/plosbiology/ar… Really excited to finally be able to share the publication of my first first-author research paper in PLOS Biology today! A Thread 🧵

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Kevin Whitley @KevinDWhitley

2 years ago

Fully funded 4-year PhD position using cutting-edge fluorescence and electron microscopy to study the bacterial cytoskeleton. 🔬🦠🦴 Co-supervised by Martin Goldberg (Durham) and Yulia Yuzenkova (Newcastle). Apply by 22 July! findaphd.com/phds/project/b…

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BladeoftheSun @BladeoftheS

2 years ago

In the USA in 1943 they produced a film 'Don't be a Sucker' about fascism. It perfectly explains Nigel Farage, Suella Braverman, Tommy Robinson and the entire Right.

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Axel Levy @axlevy0

2 years ago

We present DRGN-AI for fast, ab initio cryo-EM reconstruction! * learns a neural field from unposed images, * designed for single-shot reconstruction of unfiltered datasets, * finds new states missed by prior approaches! Teamwork led by @ZhongingAlong drgnai.cs.princeton.edu 1/

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Bardy Pavol @MojeMenoJeNikto

2 years ago

We present a preprint about a “stargate” mechanism of the capsid opening required for genome delivery in members of the Microviridae family. See below for a short manuscript summary (1/9). biorxiv.org/content/10.110…

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Francisco Tenjo-Castaño @ProteoFrankie

2 years ago

Check out our latest work on #CRISPR-associated #transposons (CAST) published in @MolecularCell! 🤩 authors.elsevier.com/c/1jCED3vVUPRm… (1/21)

Guillermo Montoya @g1_guillermo

2 years ago

We want to thank the generous funding from @ERC_Research and @novonordiskfond and that allowed us to complete this work Have a look at the follow-up twetorial by @proteofrankie explaining the findings #crispr #genomeediting #CryoEM #HorizonEU

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Jason wilson @JSamWilson

2 years ago

@ArmrYshr Do you use particle set tool to split the particles into e.g. blue and red sets depending on which initial picking they came from (this makes sense as then each round of 2D classification only sees one copy of each particle?). If so how do you do this in the particle set tool?

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Jason wilson @JSamWilson

2 years ago

@Kim_Hanseong 2D classes look great. What are your settings for 2D classification of such small particles?

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Jason wilson @JSamWilson

2 years ago

@Milan_Gerovac @JoergLab @RobLavigne1 @BoettcherCryoEM @Uni_WUE @Helmholtz_HIRI @Ko_chihara @laura241192 Do you think that some of the proteins identified in your sedimentation profiles such as HNH endonuclease (179) and DprA-like ...(207) are forming larger complexes with other proteins or are complexed with large fragments of DNA? Do you see anything in your t-SNE clustering data?