GregoryLab @GregoryLab7
Our lab are interested in understanding the non-motor manifestations of motor neuron disease including cognition and the gut-brain axis. gregorylaboratory.com Aberdeen, Scotland Joined August 2021-
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The Gregory lab are running in the Edinburgh Marathon Festival to raise money for @MNDScotland . It would mean a lot to us if you were able to make a donation 😍 @HollySneuro @FergalWaldron @ttiana_langer #JustGiving justgiving.com/team/gregoryla…
We are so lucky to have the wonderful Kristine Roberts join us in the lab to undertake a clinical academic fellowship funded by @MNDScotland
We are so lucky to have the wonderful Kristine Roberts join us in the lab to undertake a clinical academic fellowship funded by @MNDScotland
Fantastic talk from @HollySneuro of @GregoryLab7 at the @AbdnCHDS seminar today on how data-rich cohorts can be utilised to ID early biomarkers of #ALS #FTD
We (@FergalWaldron & @HollySneuro) have had a wonderful time at the @packardcenter meeting in Baltimore. It has been such a privilege to present our work and foster new collaborations. Thank you so much to everyone who made it such a special meeting. 🥰😎🇺🇸🤓
The Gregory Lab is in Lisbon for #ADPD2024 get in touch if you are interested in our work or even if you just fancy a chat 😎🤩🤓👌🏻@adpdnet @FergalWaldron @HollySneuro @jennagregory488
Final programme now online for May 15th’s meeting - ftduk.org. From digital metrics (@rhianconvery) and novel pathology (@tammarynlashley) to TBK1 models, extracellular vesicles (@slfwlr) and TDP-43 (@ASanchezAvila), with novel therapies (@orchard_tx, @alchemabtx).
#atriskalsftd #rarediseaseday The rare disease community , including ALS and FTD, needs support!
Delighted to share our new manuscript linking mitochondrial function to ALS survival time, but not to risk of ALS. doi.org/10.1016/j.heli…
Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack biorxiv.org/cgi/content/sh… 1/9
@AbdnLifeScience Medicine number 1 in UK 🥳 🎉
@AbdnLifeScience Medicine number 1 in UK 🥳 🎉
Thank you to Jenna Gregory, Ph.D. from the @aberdeenuni for the well wishes! It's a pleasure to support dedicated teams of scientists like these through our funded consortium. Together, we can change the prognosis for ALS patients. #TenYearsTALS #ALSResearch #EveryoneLives
The Gregory Lab will be in Basel next week for the international MNDA conference #alsmndsymp @mndresearch Get in touch if you want to catch up or just come and find us at the poster/presentation sessions below 🤩🤓🤗 @GregoryLab7 @HollySneuro @FergalWaldron @ttiana_langer
Feeling super Christmassy after our @GregoryLab7 Christmas night out. Love these guys #teamawesome 🥰👩🔬👨🔬🤩
We have had an fab training week with @nanostringtech getting up to speed with our new GeoMx spatial sequencing machine.
Just in time for fluorescence Friday is our new paper on LIVE-PAINT. We've shown that it can be used to image difficult-to-label proteins, and demonstrate 2-colour super-resolution imaging in live cells!! @zoegidden @EastbioDTP @EdinburghChem @EdinUni_IRR dx.doi.org/10.1021/acs.na…
Check out our ALS pre-print! We've modified our TDP-43 aptamer to work as a standard histological stain, and have shown that it detects early nuclear pathology coinciding with TDP-43 loss-of-function. dx.doi.org/10.1101/2023.1…
TDP-43APT identifies pathological TDP-43, detecting aggregation events undetectable by classical antibody stains: we show nuclear membrane staining, nucleolar decoration, nuclear puncta, nuclear rods, cytoplasmic neuronal aggregates, glial pathology.🧵2/4 biorxiv.org/content/10.110…
Euan MacDonald Centre @EuansCentre
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40 Followers 224 Following Proud mother of a toddler boy Working in the field of occupational@medicine. area of interest: gut microbiomeFantastic talk from @HollySneuro of @GregoryLab7 at the @AbdnCHDS seminar today on how data-rich cohorts can be utilised to ID early biomarkers of #ALS #FTD
#MND #ALS research hit the news recently! 📰 Researchers from @aberdeenuni and @EdinburghUni are developing a new tool which may help identify signs of MND earlier. We take a look at the research behind the headlines in our latest blog post ⬇️ mndresearch.blog/2024/04/11/a-n…
A big thank you to @SMAEurope for allowing me to present my work Microvascular dysregulation: the missing link in SMA pathogenesis? Such a fun experience!👩🔬🔬 @ParsonLab @NEAnatomist #SMACongress2024
New York, New York! 🇺🇸 #NewProfilePic
#Researcherspotlight 💡 Dr Tobias Moll from @neuroshef is investigating how communication breaks down between motor neurons. He aims to test a new potential treatment strategy and hopefully reduce damage to nerve cells. More info: mndassociation.org/research/our-r…
Thank you @packardcenter for a brilliant #ALS #MND meeting in Baltimore. Amazing science & networking opportunities, & so wonderful to meet old & new friends, scientists, & clinicians working towards the same important goal 🧪🔬👩🔬🤝🎳🌞
Fantastic event yesterday at #SMACongress2024 bringing together early career researchers and the SMA community. Thank you to @SMAEurope for organising this discussion on how the future of research can improve patient lives!
Wonderful opening session at #SMACongress2024 Excited for a week of patient, clinician and researcher collaboration! @SMAEurope @NEAnatomist @hazelAllardyce_
We (@FergalWaldron & @HollySneuro) have had a wonderful time at the @packardcenter meeting in Baltimore. It has been such a privilege to present our work and foster new collaborations. Thank you so much to everyone who made it such a special meeting. 🥰😎🇺🇸🤓
We're excited to be able to present our new work published in Acta Neuro. We show that our TDP-43 aptamer can detect an earlier form of TDP-43 pathology than is possible using antibodies in post-Mortem tissue. @EdinburghChem @EdinUni_IRR doi.org/10.1007/s00401…
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS: link.springer.com/article/10.100…
Check out our recent paper using an RNA aptamer to demonstrate nuclear TDP-43 pathology as an early event in #ALS pathogenesis 🧠
🔥🚨@TargetALS funded TDP-43 RNA aptamer published🚨🔥 Using deeply phenotyped #ALS post-mortem tissue cohorts we show nuclear TDP-43 pathology is an early event, co-incident with STMN-2 cryptic splicing, preceding cytoplasmic aggreg. & symptom onset 🧵1/6 doi.org/10.1007/s00401…
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS link.springer.com/article/10.100…
The wait is almost over! We start tomorrow at 08:00 AM! 🤩 Don’t miss the pre-conference symposium “Common Features of Neurodegenerative Disease: Exploring the Brain-Eye Connection and Beyond”. Get ready for an inspiring start of #ADPD2024 👉 bit.ly/3T90xkR
What are the biological basis of cognitive resilience to Alzheimer’s disease? Together with @Dani_edineuro we wrote a commentary on three studies published in @Brain1878 and @braincomms and propose a critical role for synaptic compensatory plasticity! 👇 academic.oup.com/braincomms/art…
Final programme now online for May 15th’s meeting - ftduk.org. From digital metrics (@rhianconvery) and novel pathology (@tammarynlashley) to TBK1 models, extracellular vesicles (@slfwlr) and TDP-43 (@ASanchezAvila), with novel therapies (@orchard_tx, @alchemabtx).
#RareDiseasesDay | At Target ALS, our commitment spans all forms of #ALS, including the rarest forms. Through collaborative efforts with esteemed partners such as @n_lorem, we are advancing drug discovery for nano-rare ALS mutations. #ALSResearch @rarediseaseday
Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains: link.springer.com/article/10.100…
#atriskalsftd #rarediseaseday The rare disease community , including ALS and FTD, needs support!