FeigeLab @FeigeLab
Translational research on Muscle and Aging biology / NIHS Nestle Institute of Health Sciences / @EPFL Ecole Polytechnique Fédérale de Lausanne Lausanne, Suisse Joined June 2019-
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FeigeLab retweeted
Online now!✨Founded by the Dutch, German, Nordic and British aging research societies, the European Federation for Aging Research (EFAR) has been launched to bring together aging researchers across Europe nature.com/articles/s4358…
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Amazing team work 🤩💪
💪new 1st author publication @grith_hojfeldt and Joris Michaud from fantastic #collaborativeScience team effort bewteen @ISMCopenhagen and Nestle @FeigeLab on the role of NAM/PN in human muscle regeneration🙌🏃🙌 advanced.onlinelibrary.wiley.com/doi/10.1002/ad…
📣important perspective: while pre specified clinical endpoints are key for hypothesis validation, open clinical exploration for hypothesis generation in humans should also be encouraged, especially to understand molecular physiology 💪🏃♀️
We wrote this letter to address the overly rigid preregistration requirements imposed now by many journals on exploratory experimental physiology research - time to align guidelines with contemporary research methods! @proferikrichter @ISMCopenhagen physoc.onlinelibrary.wiley.com/doi/10.1113/EP…
FeigeLab retweeted
New @ScienceMagazine paper from Tom Rando & colleagues: Cellular survivorship bias as a mechanistic driver of muscle stem cell aging. tinyurl.com/4h7huttj
Live imaging of dystrophic muscle stem cells 🔬 💪 Congrats @BrendanEvano, Shahragim Tajbakhsh & team 🤩 nature.com/articles/s4146…
An new finding @NatMetabolism that #NAD precursors have different kinetics in #humans linked to their metabolism by the #microbiome. NAD biology definitely has organ specific biology !!! nature.com/articles/s4225…
New clinical study from our teams @NatureComms on a #dietary intervention improving #bone and #muscle strength in young children by targeting the #microbiome nature.com/articles/s4146…
FeigeLab retweeted
It is that time again, time to vote for the 12th Annual Matt's Totally Biased (but less so) Top 10 Muscle Papers of the Year. Due to prohibitive shipping costs, this year’s winner will receive an e-gift card in lieu of a plaque. Voting will end Dec. 20. uab.co1.qualtrics.com/jfe/form/SV_51…
📢 #Heathspan accelerator program by @Nature to translate new innovations to applications 🧑🔬🔬🧫🧬🏃♀️ nature.com/immersive/heal…
A collaborative manuscript @NatureAging with Gabriele Civiletto and Philipp Gut & team on new natural molecules discovered in zebrafish that activate #autophagy and #mitophagy with benefits on #mitochondria, #BiologicalAge and #sarcopenia during aging nature.com/articles/s4358…
New mechanism of muscle growth in length
1/ Ever wondered how lifting weights makes muscles grow? 💪Our latest study reveals that mTORC1 doesn’t always hold the key. Full breakdown + preprint in this thread 👇biorxiv.org/content/10.110…
@davidjglassMD And some of the mechanisms driving energy expenditure ;-) pubmed.ncbi.nlm.nih.gov/22586266/
FeigeLab retweeted
1/10 Excited to write this thread summarizing our new paper in @NatMetabolism, which identifies a potentially critical part of the signaling pathway that drives skeletal muscle growth in response to resistance exercise! Free link rdcu.be/el9am #Myotwitter @NIH_NIAMS
FeigeLab retweeted
Join us in Lausanne 🇨🇭 for the Lac Léman Regenerative Medicine Symposium, Sept 17–19, 2025! 🔬 Stem cells, aging, bioengineering — shaping the future of regenerative medicine. habiblab.org/l2rm 🎟️ Students 25 CHF | Postdocs/Faculty 50 CHF | Industry 150 CHF #L2RM
Congrats @davidjglassMD 🤩
Congratulations David J. Glass of @Regeneron, newly inducted #NASmember! #NAS162 #medicine
FeigeLab retweeted
Online now!✨RESEARCH: using multi-omics analysis of patient samples, Zuo et al link disrupted BCAA catabolism to sarcopenia. In mouse models, they demonstrate that enhancing BCAA catabolism protects against sarcopenia nature.com/articles/s4358… rdcu.be/d9SFw
A new way to think about disrupted amino acid fluxes between #mTOR signaling and #mitochondria oxidation as a new cause of #sarcopenia
📎And see the associated News and Views by Jerome Feige here: nature.com/articles/s4358… rdcu.be/d9SFJ
A new musculoskeletal tissue is born : lipocartilage ! science.org/doi/10.1126/sc…
Converging results on impaired mitochondrial calcium as new hallmark of #aging in neurons and skeletal muscle 🧠 💪 cell.com/cell-metabolis…
New findings in mice have uncovered a crucial mechanism linking neuronal activity to mitochondrial function, researchers report in Science, revealing a potential pathway to combat age-related cognitive decline. 📄: scim.ag/3DjdseC #SciencePerspective:
🙏
Top altmetrics score 2024: #8🏆✨ @Vinz_Sorrentino, @FeigeLab (@NUSMedicine, @EPFL) and co-authors identify trigonelline as a human metabolite that can be used for NAD+ synthesis and that improves #muscle function in #aging worms and mice 💪🐭 nature.com/articles/s4225…
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