Elevate Biohacking @ElevateBiohack

Hacking Cellular Metabolism – Forcing the Fat-Burning Switch with PPARδ & Rev-ErbA Ligands Cells generate ATP via two main pathways: 1Anaerobic glycolysis (fast but inefficient, glucose → lactate, Warburg effect in many cancers) 2Oxidative phosphorylation (slower, efficient, mitochondria burning fats, ketones, etc.) Manipulating this metabolic switch is a core objective in metabolic disease research, obesity, endurance performance, and especially oncology models. Cancer cells love glycolysis for rapid proliferation + biomass. Flip the switch, starve the tumor, boost fat oxidation in healthy tissue? Game changer. Here’s where it gets interesting for research models: By introducing specific PPARδ (PPAR beta/delta) agonists (like GW501516 analogs in lab settings) + Rev-ErbA ligands, investigators can artificially force a metabolic pivot. This drives cells to rapidly upregulate fatty acid transport and oxidation genes (CPT1b, PDK4, UCP3, FABPs, etc.). PPARδ acts as a key “lipostat” – sensing fatty acids and cranking up β-oxidation machinery, mitochondrial efficiency in certain contexts, and shifting fuel preference away from glucose. Why this combo matters: •PPARδ activation: Boosts fatty acid uptake, transport into mitochondria, and oxidation. Improves insulin sensitivity, endurance-like metabolic reprogramming in muscle models, and lipid catabolism without necessarily exploding mitochondrial biogenesis. Great for “fat-adapted” phenotypes in research. •Rev-ErbA (NR1D1/2) ligands: These circadian regulators repress BMAL1 and help fine-tune metabolism. Agonists can suppress glycolysis, promote oxidative metabolism, and synergize with PPAR pathways for deeper shifts in energy homeostasis. Dual modulation hits lipid + glucose control hard. Result in models? Cells pivot hard toward fatty acid oxidation (FAO), potentially reducing glycolytic flux. Huge implications for: •Metabolic syndrome / fat loss research •Endurance / mitochondrial performance •Oncology (disrupting cancer’s preferred fuel) •Longevity & biohacking stacks exploring metabolic flexibility Important RUO disclaimer: This is strictly for educational/research purposes on cell/animal models. These ligands (especially older PPARδ agonists) have complex safety profiles and are NOT for human use. Always prioritize fundamentals: training, nutrition, sleep, bloodwork. Quality sourcing and compliance first. Who’s diving into metabolic reprogramming research right now and what are some synergies with peptides/compounds you’re studying? Drop thoughts below (RUO only). ELEVATE the signal → Follow @ElevateBiohack for more deep dives, guides, and community discussions. Code ELEVATE where it applies. What metabolic switch are you most curious about next? #Biohacking #Metabolism #PPARdelta #ResearchOnly

@dsg_dukester Good stuff! I love it lol

How are you all enjoying your Seltorexant research?!

After exploring the cosmetic and topical lineup at LP Topicals, head over to the main research site for a deeper dive into their full range of premium compounds. Longevity Peptides offers high-quality options for laboratory investigation, including lyophilized peptides, capsules, nootropics, and metabolic modulators, all supplied strictly for research purposes. The topical formulations at lptopicals.com focus on biomimetic peptides like copper peptides and advanced actives for skin renewal, barrier support, and visible anti-aging effects. Once you’ve checked those out, longevitypeptides.net expands the options with research materials designed for those studying cellular optimization, regeneration, and longevity science. Both sites emphasize purity, performance, and science-backed approaches. Whether you’re optimizing skin health through topicals or following research developments in peptides and related compounds, it’s a comprehensive resource worth exploring. #Biohacking #Peptides #Skincare #Longevity #ResearchPeptides #follicleresearch #hairgrowth

I know everyone’s used to me talking a lot about @KimeraChems all the time, but i really wanted to share another brand that I’ve been working with for quite some time now that has both men’s and women’s skincare and hair care products. lptopicals.com This line from Longevity Peptides focuses on clinical-grade biomimetic peptides, copper peptides like GHK-Cu, and targeted actives designed to support skin regeneration, barrier strength, hydration, and visible radiance at the dermal level. What makes these formulations compelling is the emphasis on purity, stability, and purposeful design. They avoid generic dilutions and prioritize high performance ingredients that integrate well into daily routines without irritation for most users. Customer feedback often highlights smoother, more hydrated skin, improved glow, and better overall tone after consistent use. For biohackers optimizing from the inside out, adding targeted topical peptides complements internal protocols by addressing skin health directly, one of the most visible markers of biological age. Results build gradually with regular application, supporting long-term dermal resilience rather than quick fixes. If you’re exploring peptide-based skincare for anti-aging, repair, or that healthy glow, check out LP Topicals at lptopicals.com. Save at LP Topicals when using code ELEVATE. What are your go-to topical peptides or skincare biohacks for skin longevity? Share your experiences in the comments. #Biohacking #Peptides #Skincare #Longevity #TopicalPeptides

SANA (MVD1): A Novel Compound Targeting Creatine-Dependent Thermogenesis for Metabolic Health I’ve been tracking emerging research compounds in the metabolic space, and SANA (MVD1), or 5-(2-nitroethenyl)salicylic acid, is generating real interest as a first-in-class small molecule. This nitroalkene derivative of salicylate is being studied as the lead candidate from Eolo Pharma for its ability to pharmacologically activate creatine-dependent thermogenesis in adipose tissue. Unlike GLP-1, GIP, or multi-agonist approaches that primarily work through appetite suppression and central signaling, SANA is designed to increase energy expenditure directly at the adipocyte level. It stimulates mitochondrial creatine kinase, particularly CKMT1A, which ramps up creatine cycling, mitochondrial respiration, and non-shivering thermogenesis. This happens independently of UCP1 and AMPK pathways, even under thermoneutral conditions. Preclinical work in diet-induced obesity models showed meaningful reductions in body weight, liver steatosis, and insulin resistance at doses far lower than traditional salicylates. Early human data from the Phase 1 first-in-human study, published in Nature Metabolism, indicated that SANA is generally safe and well-tolerated with oral dosing. Participants showed signals of increased energy expenditure, weight reduction, and improved glucose metabolism without the typical GI side effects or muscle loss concerns sometimes associated with appetite-focused agents. This mechanism opens a distinct avenue for metabolic research: boosting resting calorie burn through fat tissue energetics rather than solely relying on reduced intake. It may have relevance for obesity, metabolic dysfunction-associated steatotic liver disease, and related conditions where energy expenditure and mitochondrial function are key variables. Of course, this remains an investigational compound in active clinical development. Most data are still emerging from preclinical models and early human trials, so larger studies will be needed to fully understand long-term efficacy, optimal use, and safety profile. As with any research tool, it is supplied strictly for in vitro and laboratory investigation, not for human consumption. SANA represents an exciting shift toward directly modulating peripheral energy-burning pathways. For those deeply into biohacking metabolism, mitochondrial function, or next-generation approaches beyond incretins, it’s a compound worth following closely in the literature. Save up to 20% off at Kimera Chems when using code ELEVATE and paying with BTC. What are your thoughts on creatine-dependent thermogenesis or compounds that target energy expenditure directly? Curious to hear from others tracking this space. #Biohacking #Metabolism #Thermogenesis #ResearchCompounds

Ovamax: A Comprehensive Supplement Blend for Women’s Reproductive Health and Egg Quality Ovamax stands out as a well-formulated supplement designed specifically for women. This blend combines vitamins, minerals, and potent antioxidants including Myo-Inositol, Coenzyme Q10, Chasteberry, Folic Acid, Vitamin E, L-Arginine, Alpha-Lipoic Acid, and others. It aims to nourish ovarian function, enhance egg and embryo quality, and promote overall fertility. Ovamax works primarily by strengthening the body’s antioxidant defenses, which helps combat oxidative stress that can damage oocytes as women age or face challenges like diminished ovarian reserve. Ingredients such as CoQ10 support mitochondrial energy production in egg cells, while Myo-Inositol aids hormonal balance and insulin sensitivity, particularly beneficial for those with PCOS. Clinical interest and user reports highlight improvements in ovulation regularity, menstrual cycle balance, and better outcomes in contexts like IVF or natural conception efforts. It may also support better blood flow and reduce inflammation markers in reproductive tissues, contributing to healthier ovarian environment and potentially higher fertilization rates. For women over 30 or those focused on optimizing fertility and long-term reproductive vitality, addressing egg quality through nutrition and antioxidants is a practical strategy. Levels of key nutrients and cellular resilience naturally shift with age, making a targeted approach like this relevant for many in the longevity space. This is not a miracle solution or medical treatment. Evidence comes from ingredient studies, smaller trials, and practical use, with ongoing research like trials evaluating its impact on oocyte quality. Always consult a qualified healthcare professional before starting any supplement, especially if trying to conceive or managing specific conditions. Supplements like Ovamax illustrate how combining science-backed nutrients can support specific aspects of women’s health in a holistic way. If fertility optimization, hormonal balance, or ovarian support is part of your biohacking goals, it’s worth exploring the research and discussing with experts. Save up to 20% off at Kimera Chems when using code ELEVATE and paying with BTC. What are your experiences with fertility supplements or reproductive health biohacks? Curious to hear insights from the community. #Biohacking #Fertility #Longevity #WomensHealth

Vesugen: A Targeted Peptide Bioregulator for Vascular Health and Healthy Aging I’ve been exploring peptide bioregulators in the biohacking space, and Vesugen stands out for its focus on the vascular system. This short synthetic tripeptide (KED) is designed to support endothelial cells that line our blood vessels. Research, much of it from studies on age-related decline, suggests it helps restore vascular function, which is foundational for overall circulation, organ health, and longevity. Vesugen shows strong vasoprotective properties. It promotes endothelial repair and regeneration, potentially reducing risks associated with atherosclerosis, hypertension, and impaired blood flow. In clinical observations with older adults experiencing lower limb ischemia, it led to notable improvements in blood flow velocity. Beyond circulation, it has demonstrated geroprotective effects. Studies indicate it can slow aspects of biological aging by supporting cellular vitality in vascular tissues and other systems. It has anabolic-like actions, improves central nervous system activity in some contexts, and may offer neuroprotective benefits by supporting better microcirculation, including to the brain. Additional research points to benefits like better metabolic parameters, reduced inflammation markers in aging models, and improvements in related areas such as sleep quality and physical function. Levels of vascular resilience naturally decline with age, making targeted support like this intriguing for those focused on long-term cardiovascular and systemic health. As with other research peptides, most evidence comes from cell, animal, and smaller human studies. It is not a cure-all, and more large-scale trials are needed. Always consult qualified healthcare professionals before considering any supplementation or intervention. Peptides like Vesugen remind us how precisely we might influence specific tissues for broader anti-aging strategies. If vascular optimization or circulatory health is on your radar, it’s a compound worth tracking in the literature. Save up to 20% off at Kimera Chems when using code ELEVATE and paying with BTC. What are your experiences with vascular-focused peptides or bioregulators? Curious to hear perspectives from the community. #Biohacking #Longevity #Vesugen #Peptides

Humanin: A Hidden Mitochondrial Peptide with Real Potential for Healthy Aging I’ve been digging deeper into mitochondrial health lately, and Humanin keeps coming up as one of the most interesting endogenous peptides out there. It’s a small 24-amino acid peptide encoded in the mitochondrial DNA, first discovered in surviving neurons from Alzheimer’s patients. What started as a neuroprotective find has expanded into broader research on aging, metabolism, and cellular resilience. Humanin acts as a cytoprotective factor. It helps cells survive various stresses including oxidative damage, hypoxia, serum starvation, and toxic insults like amyloid-beta. In lab studies, it shows strong neuroprotective effects, potentially shielding brain cells and supporting cognitive function as we age. Beyond the brain, Humanin influences metabolism. It can improve insulin sensitivity, help regulate glucose levels, and support better metabolic health in animal models. Some research links it to reduced inflammation and better cardiovascular outcomes. On the longevity side, higher Humanin levels correlate with better healthspan and, in some studies, increased lifespan in models like C. elegans. Treating middle-aged mice with a potent analog improved metabolic parameters, reduced inflammation, and supported overall vitality. Levels naturally decline with age, but they’re notably higher in centenarians and their offspring. This isn’t hype or a magic bullet. Most data comes from cell and animal studies, with promising but limited human evidence so far. Biohackers and researchers are exploring ways to support mitochondrial peptide function through lifestyle, exercise, or targeted approaches, but always consult professionals before considering any interventions. Mitochondrial-derived peptides like Humanin highlight how much we still have to learn about our own biology and cellular signaling. If you’re into optimizing energy, resilience, and long-term health, it’s worth following the research. Save up to 20% off at Kimera Chems when using code ELEVATE and paying with BTC. What are your experiences or thoughts on mitochondrial peptides? Curious to hear from others tracking this space. #Biohacking #Longevity #Mitochondria

Stepped back into the tactical community and damn, I’m genuinely amazed at how much has shifted in such a short time. Everywhere I turn — group chats, range days, gym conversations — I’m getting hit with nonstop questions about peptides. Guys who used to only talk about putting on size, training protocols, and recovery stacks are now deep in the weeds on glp’s and other peptides. The curiosity level is through the roof. People want to know what actually works in the field: faster injury recovery, better sleep, joint resilience under load, cognitive edge… all while staying mission-ready. The GLP-1 train? It’s not just rolling — it’s full steam ahead. I’m seeing a noticeable culture shift. A solid chunk of the same high-performing dudes who were all about “get massive” a couple years ago have completely flipped the script. They’re now focused on getting lean, ripped, and functionally optimized. Dropping the extra fluff while keeping (or even building) performance. Better body comp, sharper energy, improved metabolic health, and that dialed-in look that still screams capable instead of bulky. The before/after stories I’m hearing are legit impressive. It’s wild how fast the tactical/biohacking overlap has accelerated. What started as fringe conversations in certain circles is now mainstream in the community. Guys are prioritizing longevity, recovery, and sustainable performance over just chasing size. Smart move when your job (or life) can demand everything from you at a moment’s notice. If you’re in the tactical space and exploring peptides or GLP-1s, I’d love to hear your experience below. What’s worked for you? What questions do you still have? The conversation is evolving fast — glad to be back in it. #Biohacking #Peptides #GLP1 #TacticalAthlete #OptimizeOrDieTrying @ElevateBiohack

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Your research deserves better than sketchy “bac water.” Most bacteriostatic water out there right now? Straight garbage, especially with all the fake “hospira”. No real testing. No transparency. Just repackaged mystery liquid from who-knows-where. 99% of it fails basic sterility and purity standards that actual researchers need. That’s why I only use Kimera Chems Sterile Research Diluent. This isn’t some corner-cut product. Kimera’s diluent is: •Properly sterile •3rd-party lab tested for purity, endotoxins, and sterility •Made for serious research applications •Consistent batch after batch When your peptides, SARMs, or other compounds are on the line, you can’t afford contamination or unknown variables. Your research deserves quality. Elevate your research with Kimera. If you’re tired of rolling the dice with cheap bac water that could compromise your entire experiment, make the switch. Use code ELEVATE and save up to 20% when you pay with BTC. Quality isn’t optional in research. Elevate your standards. Elevate with Kimera Chems. #ResearchChemicals #PeptideResearch #Biohacking #KimeraChems kimerachems.co/product/steril…

Yeah my labs stayed in normal range but I know what you mean..a few buddies and some reports I’ve seen mentioned them spiking with IGF1 LR3 but nothing crazy high. For me it wasn’t an issue, my doc monitors all that before and after, but if something is borderline high before then he won’t put someone on it. Did yours jump pretty high? How long were you on it when that happened?

Elevate Guide: IGF-1 LR3 and Hexarelin – Two of The First Peptides I Ever Ran (Prescribed Too) That Really Got Me Into This World. I wanted to talk about two peptides that really got me started in all this: IGF-1 LR3 and Hexarelin. These were the very first ones I tried, and they were actually prescribed to me by a clinic back then. They played a big part in pulling me deeper into peptides, and honestly, I saw some real, solid gains from them. If you’re looking around for options while things tighten up with HGH availability, I figured sharing my experience might help. How I Got Started With Them At the time, I was already putting in the work with training, sleep, and nutrition, but I was curious about that next level for recovery and how my body was responding. The clinic checked my labs, saw some areas where GH and IGF-1 pathways could use support, and suggested these two. It felt like a thoughtful way in, not just jumping straight to the big stuff. Hexarelin was the one that kicked up my own growth hormone release. It’s a strong GHRP that prompts solid pulses from the pituitary. For me, it helped with deeper sleep and bouncing back quicker between workouts, plus it supported my appetite during harder training phases. IGF-1 LR3, on the flip side, worked more directly on the growth and repair side. The LR3 version lasts longer in the system, and I noticed it in better muscle fullness, faster healing from tough sessions, and some nice improvements in body composition over time. Running them together made a lot of sense. Hexarelin helped upstream with natural GH output, while the IGF-1 LR3 gave that extra push where it mattered for muscle and recovery. It felt like a good balance that kept things moving without overcomplicating my routine. What I Actually Experienced I remember noticing changes within a few weeks. Recovery was better—those lingering sore muscles didn’t hang around as long, and I could push a bit harder in the gym without feeling completely wiped out. There was more muscle fullness and a bit better vascularity, even on normal days. Sleep improved too, which just made everything else click into place. It wasn’t some crazy overnight shift, but steady progress that kept me interested and motivated to learn more about peptides. #Biohacking #Peptides #IGF1LR3 #Hexarelin #GrowthHormone #Recovery #MuscleGains #PeptideTherapy #Biohacker #HGHAlternatives elevatebiohacking.com/2026/06/03/ele…

@brandonschubert @KimeraChems The only place out there testing there research diluent!🔥

@PigPen_forever @finnrick_tests @Krysia830073 @PeptidePartners @DailyPeptide @clearbatchnet @PeptidesHub @CHUGGERS14 @TrustPointe @ArdRix1 @peptidedaily_ x is filled with “auditors”…what are they getting out of it?

Did i mention SLU-PP-915 is available now at @KimeraChems ? Save up to 20% off when you pay with BTC at checkout and use code ELEVATE. The ERR agonist space just got a practical upgrade with SLU-PP-915. For two years everyone was hyped on SLU-PP-332 as the “exercise mimetic” that boosted endurance ~50% in mice, but it was mostly injection-only with trash oral bioavailability requiring many people to need super high mg doses.. 915 from the same Saint Louis University lab fixes that. New thiophene + boronic acid structure makes it orally bioavailable while still hitting all three ERRs cleanly (alpha, beta, gamma). It matched the old one for running performance in mice when taken orally, cranked exercise-related genes like Ddit4, and stacked nicely with actual training. Big potential around mitochondrial function, fat oxidation, and endurance without the needle hassle. 332 proved the concept. 915 makes it more usable for real research. #Biohacking #SLUPP915 #ExerciseMimetic #ERRAgonist #Mitochondria #Longevity #Peptides #PerformanceEnhancement #ElevateBiohacking (For lab research only - not for human use)

SLU-PP-915 Code KIMERA10 for 10% off The ERR-agonist research space has centered on one molecule for two years. SLU-PP-332 got the attention -- pan-ERR agonist, a reported ~50% increase in endurance capacity in sedentary mice, widely tagged in coverage as an "exercise mimetic." The limitation that held it back as a research tool: 332 has poor oral bioavailability and is active mainly by injection in animal models, which narrows the chronic oral-dosing studies it can support. SLU-PP-915 addresses that limitation. Same lab (Burris group, out of Saint Louis University), same target, different chemistry. Where 332 is built on an isoxazole, 915 is a 2,5-disubstituted thiophene carrying a boronic acid moiety. That structural pivot is the whole story: 915 is orally bioavailable and holds up in vivo while keeping the pan-agonist profile across all three estrogen-related receptors. The design route is worth knowing. 915 came out of the ERRgamma ligand-binding crystal structure solved with GSK-4716, a known acyl-hydrazide agonist. The team swapped the central hydrazide for a five-membered heterocycle and worked through a series of disubstituted thiophenes; the boronic-acid analog fell out as the lead. Structure-guided, not a screening accident. The numbers: ERRalpha -- EC50 ~414 nM ERRbeta -- EC50 ~435 nM ERRgamma -- EC50 ~378 nM ERRs are orphan nuclear receptors. Despite the name they are not driven by estrogen -- they are master regulators of mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation, and the Krebs cycle, upstream of how a cell partitions and burns fuel. That is the same transcriptional axis sustained aerobic training remodels over time. The premise behind the ERR agonist programs is to activate that program pharmacologically rather than through the physiological exercise stimulus. What the preclinical work shows for 915: Aerobic capacity. In mice, 915 improved running distance and duration on par with 332 when dosed IP, with comparable efficacy orally once exposure is accounted for. That oral durability is the reason the molecule was made. Ddit4 induction. 915 drove DNA-damage-inducible transcript 4 -- an acute-exercise-responsive gene -- to levels matching or exceeding treadmill running in mice, depending on the muscle examined. Notably it stacked with training in the model rather than substituting for it: animals that ran AND received 915 showed further elevation in Ddit4 and mitochondrial gene expression beyond either condition alone. Cardiac metabolism. Work on the pan-ERR series in pressure-overload heart failure models showed improved pumping function, driven mainly through ERRgamma, via upregulated cardiac fatty acid metabolism and mitochondrial function, without worsening hypertrophy. There is an autophagy angle too: ERR activation induced the autophagy-lysosome pathway through TFEB in cardiomyocytes. Indications discussed in the literature for the class: obesity, type 2 diabetes, MASH, heart failure, sarcopenia, and the muscular dystrophies -- broadly, conditions where mitochondrial output and oxidative capacity are rate-limiting. All preclinical. One analytical note on how the field is treating this class. 915 has already been run through LC-HRMS/MS metabolite characterization, with seven Phase-I metabolites mapped and reference work done for anti-doping screening. Detection methods getting built this early, well ahead of any approval, is a marker of how seriously the analytical community is taking ERR agonists. Structurally it is a clean small molecule: C17H13BFNO3S, MW ~341.2, CAS 2285432-92-8. The boronic acid is not decoration -- it is the feature that delivered oral exposure. 332 established the mechanism in vivo. 915 makes that mechanism tractable for oral, longer-duration preclinical study. For laboratory research use only. Not for human consumption. Not a drug, supplement, or medical product. Nothing here is medical advice or a claim of safety or efficacy in humans.

Yeah i like 2ius before bed. I still have some hgh stockpiled, but most of the good overseas vendors with high quality stuff just arent shipping it reliably if at all anymore. Adding in that low dose igf1 lr3 post workout with carbs could be a nice way to push things further without needing to crank the growth dose too much. Solid plan picking some up. Appreciate the kind words on the post brother.

@MattLasky And a little oxandralone courtesy of Empower Pharmacy. lol

Yeah man low dose IGF1 LR3 post workout with carbs is a smart move. Thats pretty much how I first ran it too. It lines up the insulin effects so they help instead of causing issues. A lot of the bad talk comes from people slamming higher doses without proper timing or food around it then complaining about the lows or feeling off. At 20 to 40mcg right after training with a good carb and protein meal it can really add something noticeable for recovery and that fuller look. Just keep an eye on your blood sugar especially if youre sensitive and dont run it nonstop. Short cycles felt best for me.