Dermal Cell News @DermalCell
An online resource for researchers studying dermal tissue. Part of the @STEMCELLTech Science News service. dermalcellnews.com Joined February 2015-
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Dr. Aneta Skaradzińska and co-authors provides an overview of current advances in #bacteriophage-based approaches for the treatment of cutaneous infections and #SkinDisorders. #OpenAccess 🔓 🔗 bit.ly/4gmCH15
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In this @NatureComms investigation, researchers map the #fibroblast transcriptional response to stretching in vivo and demonstrate that stretching forces fibroblasts to exit their #quiescent state and restart proliferation. 🧫 Check it out: go.nature.com/4vGA3HT
Investigators develop a physiologically relevant 3D #melanoma skin model that captures tumor–microenvironment interactions and enables more realistic assessment of targeted therapies. Discover more here: ▶️ bit.ly/4vIf2fU
In this study, investigators from the University Hospital Zurich and the University of Zurich show that NLRP1 inflammasome activation in #keratinocytes drives #psoriasis-like inflammation through an IL-1–IL-36γ signaling axis, identifying a potential therapeutic target. 📝 go.nature.com/49VyNsh
Researchers show that IDH gain-of-function mutations are linked to immune exclusion and poor response to anti-PD-1 therapy in melanoma, highlighting a potential mechanism of immunotherapy resistance. bit.ly/4xm4IMq
Researchers show that #keratinocytes drive T cell activation in #psoriasis through a RUNX1–GCN5–ICOSLG signaling axis, identifying GCN5 inhibition as a potential therapeutic strategy. 🔓 #OpenAccess Learn more: 🔖 go.nature.com/4xi7LFe
This @CellReports study identifies an extracellular vesicle-antibody axis that constrains #melanoma survival signaling and has biomarker and therapeutic implications. 🔓 #OpenAccess | bit.ly/4e5dF3X
Scientists with Dr. @archana_biology investigated the protective role of microRNA-31-5p, which is elevated in #vitiligo lesions, against UV-B-induced DNA damage in #keratinocytes. @CSIR_IND 🤩 Read the study in @SciReports: go.nature.com/4ecdxQm
The future of early cutaneous squamous cell carcinoma (#CSCC) management lies in response-adapted strategies to tailor the extent of surgery, radiation, and systemic therapy. 📖 Learn more in this @jitcancer review: bit.ly/4u4WR2R
Researchers with Drs. Jing Jia & Zhengjun Li observe a positive correlation between PHF20 expression and the malignancy and tumor grade of cutaneous squamous cell carcinoma (#cSCC). 📈 go.nature.com/49AQ4Xx Functional studies suggest that PHF20 promotes #oncogenic phenotypes, including proliferation, invasion, and EMT.
🧫 This review highlights advances in complex 3D in vitro systems — including full-thickness human skin equivalents, #organoids, and microphysiological platforms. bit.ly/4o0Jwr9 They discuss how these emerging models can be leveraged to interrogate aging biology and support translational research. 🗣️
Scientists demonstrated a novel facet of GSDME as an epigenetic modifier that promotes #melanoma development through the regulation of the centriole biogenesis regulator PLK4. @cddpress | go.nature.com/4o1dqvq
This Phase I/II, open-label, multicenter study evaluated drug combinations in patients with metastatic #melanoma and cutaneous squamous cell carcinoma. Learn more! 👇 @jitcancer | bit.ly/4wSU67l
Mona Foth and scientists at @UUtah found that both compounds demonstrated potent anti-proliferative activity against NRAS-mutated #melanoma cell lines and robust anti-tumor activity against preclinical melanoma models. @CR_AACR | bit.ly/4nU1ueH
💡 Researchers at @MoffittNews identified the small MAF family transcription factor MAFG as a critical regulator of MITF activity and melanoma cell state plasticity. @NatureComms | go.nature.com/4nS5gp2
💡 Check this out! Chris Ke Bai and researchers at @Cornell showed that H3K9me3 deposition is dynamic during epidermis morphogenesis and essential for lineage diversification. @NatureComms | go.nature.com/4u1W82x
The expression and role of catestatin (CST), a chromogranin A-derived peptide with immunomodulatory and reparative properties in skin injury, led a @UCSanDiego team to examine its connection to #melanoma. Learn more in their @oncogenejournal study. 🔗 go.nature.com/49K3b8I
This @cddpress study determined that lysine-specific histone demethylase 1 (LSD1) expression is upregulated in metastatic #melanoma relative to primary melanoma, which is indicative of a poor prognosis. 📚 Learn more: go.nature.com/49IFQnQ
Short-term sodium dodecyl sulfate exposure rapidly disrupts human #SkinBarrier integrity through oxidative stress-driven suppression of structural/immune mediators and activation of stress/remodeling pathways, reports a University of Zurich team. 🔗 bit.ly/3RzjKxS
The orchestrated network of skin photoaging. 🆕 The authors discuss the cellular and molecular mechanisms underlying skin photoaging, and details the roles of and reciprocal crosstalk among fibroblasts, keratinocytes, and #melanocytes. 📚 bit.ly/4nD3RTd
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