Biology of Sex Differences @BiologySexDiff
BSD is the journal of the Organization for the Study of Sex Differences (@OSSDTweets) and a publication of the Society for Women's Health Research (@SWHR). bsd-journal.com Joined June 2011-
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New article: "Despite previous research focusing on neuronal connectivity and transcriptomics, there has been a gap in understanding pyramidal neurons characteristics across subregions and between sexes," authors write. Read their findings: ow.ly/atFT50Rh09L
New article: Authors tested whether female neonatal hippocampal neurons express autonomous neuroprotective properties and assess the ability of testosterone (T) to alter this phenotype. Read the results: ow.ly/EV8j50Rh08F
Correction: Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats ow.ly/RVYH50Rh05B
New article: In this review article, authors explore the current research of how sex as a biological variable #SABV influences several distinct motivated behaviors that are modulated by the melanin-concentrating hormone (MCH) neuropeptide system. bsd.biomedcentral.com/articles/10.11…
New article: Authors evaluated three sets of publicly available online training materials on how to account for sex in biomedical studies. Their findings suggest a need for revised or new training materials in this area. Learn more: ow.ly/1BR750Rh02s
#WomensHistoryMonth Wednesday: In 2010, SWHR and @OSSDtweets founded the peer-reviewed, open-access academic journal Biology of Sex Differences, @BiologySexDiff. Explore the history of #WomensHealthResearch in the SWHR timeline: swhr.org/about/history/…
New paper "Sex and statin-related genetic associations at the #PCSK9 gene locus" at @BiologySexDiff: bsd.biomedcentral.com/articles/10.11…. Thanks to all my collaborators @GenStatLeipzig, @KronenbergLab, and the teams from #LURIC, #TwinGene, #GCKD and #KORA! A short thread follows
New paper out! We evaluated publicly available training materials on how to incorporate sex/gender into research. Our finding: there is room for improvement. @annikagompers @madi_olivier @BiologySexDiff bsd.biomedcentral.com/articles/10.11…
New work investigating neural patterns of pubertal timing in females with @gottschewsky & @TobKaufmann now out in @BiologySexDiff 🧠🚨
New work investigating neural patterns of pubertal timing in females with @gottschewsky & @TobKaufmann now out in @BiologySexDiff 🧠🚨
A great job with @Neuropsychopha2 Check out our latest work in @BiologySexDiff on how the deficiency in PAPP-A2, an essential factor in the GH/IGF-1 axis that causes growth deficits has a sex-dependent differential impact and how we address its treatment
A great job with @Neuropsychopha2 Check out our latest work in @BiologySexDiff on how the deficiency in PAPP-A2, an essential factor in the GH/IGF-1 axis that causes growth deficits has a sex-dependent differential impact and how we address its treatment
So excited for this work to be published
So excited for this work to be published
New article: This study "aimed to evaluate whether Pappa2 deficiency and pharmacological manipulation of the insulin-like growth factor-1 system are associated with sex-specific differences in growth-related signaling pathways." ow.ly/Yz4950Rh00w
New article: "Sex and gender-specific treatments are unrealistic, and our translational goal should be adaptation of treatment to the variable effects of sex and gender on targetable pathways," authors write. Read the research: ow.ly/ukR050RgZYz
Biology of Sex Differences invites SCOR(E) Directors to submit articles from Specialized Centers of Research (Excellence) addressing #gender #SexDifferences in social determinants of health as it pertains to their health topics of focus. Due Nov 2024: biomedcentral.com/collections/SG…
New article: These study results found that violence exposure was associated with slower, more adult-like heart rate and that girls showed greater posttraumatic stress symptoms associated with slower HR while boys did not: ow.ly/FS4F50R50eE
New article: Authors investigated if pre- vs. post-menarche status can be classified using machine learning on cortical and subcortical structural magnetic resonance imaging #MRI data: ow.ly/lm5G50R38gT
#FlashbackFriday This 2016 study showed the #SexDifferences in intestinal and peripheral immune populations, which could underlie sex differences in intestinal disorders like IBD and other intestinal-related diseases. ow.ly/9vXM50Q13mw
New article: Using rodent models of Preeclampsia (PreE; new onset of hypertension after 20 weeks gestation) and HELLP (hemolysis, elevated liver enzymes, and low platelets), authors studied the behavioral outcome of offspring in adolescence: ow.ly/nOeq50R384l
New article: Authors studied whether the sex-differential effects of statin treatment affects on Proprotein convertase subtilisin/kexin type 9 levels can be explained by genetics: ow.ly/xX4V50R37ZE
New article: In this study, authors employed a computational predictive algorithm for cell conversions to predict the transcription factors (TFs) required for direct reprogramming of human dermal fibroblasts into Sertoli cells: ow.ly/LV4C50R13Hs
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Male & female immune pathways are known to differ. No surprise, then: folk w/ cancer may not respond to the same immunotherapy if they’re differently sexed—the future of individualized medicine depends on research like this!
New article: "There is an ongoing debate on whether sex affects immune-suppressive tumor microenvironment and immunotherapy," authors write. They studied sex dimorphisms & its impact on the efficacy of #immunotherapy in esophageal #cancer: ow.ly/mxWX50QVzpp
New paper "Sex and statin-related genetic associations at the #PCSK9 gene locus" at @BiologySexDiff: bsd.biomedcentral.com/articles/10.11…. Thanks to all my collaborators @GenStatLeipzig, @KronenbergLab, and the teams from #LURIC, #TwinGene, #GCKD and #KORA! A short thread follows
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring | | Full Text @BiologySexDiff bsd.biomedcentral.com/articles/10.11…
@DrAntonioRiva @GabrieleMocciar @Sara_Campinoti @UrbaniLab @ChokshiLab
New article: "There is an ongoing debate on whether sex affects immune-suppressive tumor microenvironment and immunotherapy," authors write. They studied sex dimorphisms & its impact on the efficacy of #immunotherapy in esophageal #cancer: ow.ly/mxWX50QVzpp
New paper out! We evaluated publicly available training materials on how to incorporate sex/gender into research. Our finding: there is room for improvement. @annikagompers @madi_olivier @BiologySexDiff bsd.biomedcentral.com/articles/10.11…
New work investigating neural patterns of pubertal timing in females with @gottschewsky & @TobKaufmann now out in @BiologySexDiff 🧠🚨
New article: Authors investigated if pre- vs. post-menarche status can be classified using machine learning on cortical and subcortical structural magnetic resonance imaging #MRI data: ow.ly/lm5G50R38gT
A great job with @Neuropsychopha2 Check out our latest work in @BiologySexDiff on how the deficiency in PAPP-A2, an essential factor in the GH/IGF-1 axis that causes growth deficits has a sex-dependent differential impact and how we address its treatment
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments. bsd.biomedcentral.com/articles/10.11… @_ibima @InfoUMA @BioMedCentral @fibhnjs
So excited for this work to be published
New article: Using rodent models of Preeclampsia (PreE; new onset of hypertension after 20 weeks gestation) and HELLP (hemolysis, elevated liver enzymes, and low platelets), authors studied the behavioral outcome of offspring in adolescence: ow.ly/nOeq50R384l
Now live: A special, interdisciplinary focus issue on sex and gender in science from @CellCellPress! 🧵
Great work here. So important not to rest on our tiny laurels—there’s work to do to drive this paradigm shift forward. Policy shifts aren’t enough, we need intergenerational buy in!
New article: Authors here developed a scoring system to evaluate the inclusion of biological sex in manuscripts published in #Diabetes, a journal published by the American Diabetes Association. Read the findings: ow.ly/1a1w50QIel1
Very proud of this paper and the team of undergraduates and graduate student Celena Cherian who did the work 🤩 We can all work together to increase consideration of biological sex in biomedical and clinical research @CIHRIGH @ResearchonWH @WomensResearch
New article: Authors here developed a scoring system to evaluate the inclusion of biological sex in manuscripts published in #Diabetes, a journal published by the American Diabetes Association. Read the findings: ow.ly/1a1w50QIel1
Confused about human brain #sexdifference? So are the data. See my new paper @BiologySexDiff, “Remembering the Null Hypothesis…” rdcu.be/dykLd, in response to @AlexDeCasien et al. 1/3
@Lise_Eliot @BiologySexDiff @AlexDeCasien Nicely argued! Spurious sex differences at the molecular level in humans are also, unfortunately, widely over-estimated and over-interpreted. pubmed.ncbi.nlm.nih.gov/34674833/
"Studying only one sex when developing new treatments misses a whole spectrum of information on how a drug works," @TrialsArena writes. A study found females were only 34% of participants in industry-sponsored early-phase trials: ow.ly/4FE850Qupuq #WomensHealthResearchDay
Did you miss our #FORWH conversation with Dr. Janine Clayton @JanineClaytonMD from @NIH_ORWH this week? Don't worry! You can catch the full conversation online here, just in time for #WomensHealthResearchDay. Watch now: ow.ly/g3pV50QtJNT
It's been 8 years of #SABV, but >30y since NIH mandated incorporation of women in NIH-funded clinical trials. Yet how many papers examine whether or not sex/gender makes a difference? ~5% (~20% use sex/gender as a covariate (removing any effect not learning from any effect).
Today is #WomensHealthResearchDay! Jan 25 marks the anniversary of the implementation of the NIH Policy on Sex as a Biological Variable #SABV in 2016 and serves as an opportunity to reflect on how far women’s health research has come – and how far we have to go.
Read SWHR’s letter to the White House: swhr.org/swhr_resource/… #WomensHealthResearchDay
"We believe this new White House Initiative has the potential to remedy decades of lost research into the health of women, spurring innovation and advancing knowledge, and, ultimately, transforming how we view women’s health in the United States," SWHR writes.
The new White House Initiative on Women’s Health Research, led by First Lady Jill Biden @FLOTUS and the @WhiteHouseGPC, is an important step in prioritizing women’s health research at the federal level. #WomensHealthResearchDay
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