Basile Wicky @BasileWicky
Protein design & synthetic biology • Asst. prof. @ETH_BSSE Basel, Switzerland Joined July 2020-
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Basile Wicky retweeted
#JobAlert 🚀 Exciting opportunity for young scientists - please share: tinyurl.com/2rajyepc @ETH_en #BIIE @BaselStadt
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We're hiring! If you're interested in applying protein design to improving AAV we'd love to hear from you! Fully-funded 2 year collab postdoc between my group at ETH D-BSSE (in Basel) and Denis Phichith at Roche. Job description and application portal: lnkd.in/e3P7HXt4
New lab preprint! We used design to sample protein space, and developed a HT NMR pipeline to analyze 384 designs; a first glance into seq-struct-dynamics at scale! An exciting collaboration with @HillerLab, and @DlanAbr's first paper! biorxiv.org/content/10.648…
Basile Wicky retweeted
Super excited to share our paper “Design of amyloidogenic peptide traps” is out now! 🧠 nature.com/articles/s4158… Special thanks to @eaandrzejewska , Danny Sahtoe and David Baker
Basile Wicky retweeted
Short summary thread of our recent review on de novo protein design: (Poster-sized figure (36 x 48 inches) for printing: drive.google.com/file/d/1sG3OlE…)
Sparks of function by de novo protein design go.nature.com/48jXz1z
@karina_pombo That's amazing!! Congrats!!
Basile Wicky retweeted
I keep on preaching to my lab about the usefulness @ChatGPTapp for coding, but real-life demos might be more effective. A thread on a neural network we quickly developed to classify antibiotics sensitivity 🧵 (1/10)
Basile Wicky retweeted
The commentary I wrote is now live at Nature Biotech: nature.com/articles/s4158… (free version rdcu.be/dwSSy).
Continuous directed evolution is so cool 🥹
Excited to share - EcORep! Now you can simply electroporate a PCR product into E. coli and let the linear DNA replicate orthogonally in the cell. EcORep can be used to evolve proteins rapidly and continuously! science.org/doi/10.1126/sc…
Basile Wicky retweeted
LigandMPNN preprint: biorxiv.org/content/10.110… LigandMPNN inference code + model weights (including ProteinMPNN, SolubleMPNN etc): github.com/dauparas/Ligan…
Beautiful work by the talented @KieraSumida and Reyes! Their findings on the quantitative tradeoff between seq conservation, designability and function (fig. 3f/g) is particularly insightful, and will be useful for many future protein engineering efforts!
Our paper using ProteinMPNN redesign for improved properties is up on JACS! Huge thanks to Reyes, @ikalvet, Sam, and many others for their work. Shout out to @JustasDauparas for developing such a groundbreaking (and versatile!) tool. @UWproteindesign pubs.acs.org/doi/full/10.10…
Basile Wicky retweeted
#openposition Exciting opportunity for a #postdoc: be part of the partnership @ETH_en and @Roche and become a Next-Gen Bioengineer > u.ethz.ch/m4Lwj Thanks for sharing!
Basile Wicky retweeted
Expanding protein pore palette beyond biology. Computational design of protein pores with various shapes and sizes. (Potential applications: Nanopore sensing, DNA/Protein sequencing, Custom pores for selective membranes and ligand-gated channels for cellular delivery.....)
Basile Wicky retweeted
We are hiring! Come join us for a PhD in Computational Language Evolution @ETH in Basel @ETH_BSSE and the National Research Program on Evolving Language @NCCR_Language. We are looking forward to receiving your application jobs.ethz.ch/job/view/JOPG_…
Basile Wicky retweeted
We're looking for a PhD student interesting in protein design and tech development. Exciting project interfacing protein @structbiolbxl and solid-state nanopores @imec_int. Computational design of hybrid nanopore sensors. Apply by December 15th! imec-int.com/en/work-at-ime…
Basile Wicky retweeted
Dorado v0.5 NCM release 🎉 - new simplex models - faster - higher accuracy - easier to use (auto model selection) - hemi-methylation (duplex mods) - primer & adapter trimming - custom barcodes #nanoporeconf github.com/nanoporetech/d…
Basile Wicky retweeted
Is binarization of scATAC-seq data really necessary? The conclusion from our analysis is that a quantitative treatment is in fact beneficial. Now out in Nature Methods! @gagneurlab @fabian_theis nature.com/articles/s4159… Many additions since the preprint 👇(1/n)
Basile Wicky retweeted
For anyone interested in generating publication-quality secondary structure diagrams from PDB files, SSDraw is available and now published by @ProteinSociety onlinelibrary.wiley.com/doi/full/10.10…
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