Gyanu Lamichhane @BacteriaLab
Interests: Bacteriology and antibiotic resistance. Critical thinking. Apolitical. I see glass quarter full. sites.google.com/view/lamichhan… Baltimore, MD Joined January 2019-
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Drs. Story-Roller and Pankaj Kumar from our group have led multiple studies providing both molecular mechanistic basis and evidence for efficacy of dual b-lactams vs Mycobacterium abscessus. Here are our publications: sites.google.com/view/lamichhan…
Drs. Story-Roller and Pankaj Kumar from our group have led multiple studies providing both molecular mechanistic basis and evidence for efficacy of dual b-lactams vs Mycobacterium abscessus. Here are our publications: sites.google.com/view/lamichhan…
A good example of a new frontier. Exciting.
Very exciting concepts at the interface of chemistry and infection biology that focus on unexplored yet fundamental aspects of bacterial cell wall.
Very exciting concepts at the interface of chemistry and infection biology that focus on unexplored yet fundamental aspects of bacterial cell wall.
Below a cool teaser of what the microscopy setup from our latest preprint can do. Here, a Salmonella bacterium (arrow) divides on the surface of human intestinal cells. It then invades, and the epithelial cell reacts by instantly killing itself.
Thank you for sharing this. A+ grade evidence of sensing and phagocytosis by a neutrophil. And also of cell polarity and kinetics of cytoskeletal rearrangement to achieve motility. Anyways, how is the neutrophil anchored to the glass tube?
Thank you for sharing this. A+ grade evidence of sensing and phagocytosis by a neutrophil. And also of cell polarity and kinetics of cytoskeletal rearrangement to achieve motility. Anyways, how is the neutrophil anchored to the glass tube?
Indeed please join the effort. Antibiotic development/discovery is one of the main challenges of our times as several bugs have become resistant to many Abx we have. A good blog to read more about the need for new Abx is …ibiotics-theperfectstorm.blogspot.com.
Indeed please join the effort. Antibiotic development/discovery is one of the main challenges of our times as several bugs have become resistant to many Abx we have. A good blog to read more about the need for new Abx is …ibiotics-theperfectstorm.blogspot.com.
This series has been a go-to reference for many protocols we use. Thank you for putting these together.
This series has been a go-to reference for many protocols we use. Thank you for putting these together.
Indeed an interesting microbe. Amazing heterogeneity in geno- and phenotypes. A bit more finicky compared to other mycos. Learned much and continuing to learn from this myco..
Indeed an interesting microbe. Amazing heterogeneity in geno- and phenotypes. A bit more finicky compared to other mycos. Learned much and continuing to learn from this myco..
An interesting protein with domains reminiscent of a classical PBP, but it also exhibits a strong b-lactamase activity. M. abscessus mutant lacking this protein grows as a single clump and is wiped out from the lungs of mice...Thx @GlcNAcMurNAc for sharing this.
An interesting protein with domains reminiscent of a classical PBP, but it also exhibits a strong b-lactamase activity. M. abscessus mutant lacking this protein grows as a single clump and is wiped out from the lungs of mice...Thx @GlcNAcMurNAc for sharing this.
Our team has taken one step towards addressing the challenge of developing new #antibiotics. Early results show promise but much work lies ahead to develop one that is useful bedside. We're determined to fight against #AMR, #TB and #mycobacteria. Our paper nature.com/articles/s4200…
Dear graduate students, let this sink in. If you want to read more about what Albert did, I recommend the novel 'the greatest story never told' by Frank Ryan. Just like Albert's, your contributions are much needed and will be valuable to humanity.
Dear graduate students, let this sink in. If you want to read more about what Albert did, I recommend the novel 'the greatest story never told' by Frank Ryan. Just like Albert's, your contributions are much needed and will be valuable to humanity.
You may wonder what else kills 1.5 million a year. It's tuberculosis. TB is completely curable & preventable, but because it only kills people in the developing world, those of us with privilege ignore it. Of course we want a Covid vaccine - but let's fix TB too!
New investigators bringing their ideas and energy is always a good thing, for any field. You are welcome. Glad you are focusing on Mtb also.
New investigators bringing their ideas and energy is always a good thing, for any field. You are welcome. Glad you are focusing on Mtb also.
To teach our kids real life skills - on Sundays they are allowed to run their home cafe for the family. Mom and I mentor and are loyal (only) customers. The two make their own menus and get to keep the money they make. They collaborate and compete. Here is the menu.
Through this, your Dad also inspires others. You will be an inspiration for many from your town (and beyond).
Through this, your Dad also inspires others. You will be an inspiration for many from your town (and beyond).
Luiz Pedro Carvalho @LuizCarvalhoLAB
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38 Followers 107 FollowingRock Lab 🧬🧫 @RockLabTB
1K Followers 340 Following Rock Lab @RockefellerUniv. Tuberculosis functional genomics. This account is run by overly enthusiastic grad students.@NSpottiswoodeMD @BacteriaLab is the master of this domain!
This is a must read! There is so much €$¥# out there on “efflux” in Mtb, that really amounts to nothing. Thank you for writing this up.
Great work led by @jaryd_sullivan Learned a lot through this project from @KremerLaurent1 and all the other collaborators. Any advice how to go from paper to patients? @aledmedwards, others?
Efficacy of epetraborole against #Mycobacterium abscessus is increased with #norvaline New research from @jaryd_sullivan, @mbehr_mcgill and colleagues @mcgillu buff.ly/3v5IYEZ
It is incredible to me that these drops of liquid contain 188 #SARSCoV2 genomes between the two of them. Also, that I’m only using about 15% of each! #SequenceAllTheCOVIDS @hmostaf2 @nanopore @NetworkArtic
So proud of this team & their creative scientific brainstorming at the annual lab retreat! Amazing ideas (Plus, boy can they cook, yum!) Excited but sad to send Shalika off to be asst prof @gopioneers- all the best! So help our team grow- come join us! See details 👇
#PLOSPathogens: Several years of hard work by Dr. Shivangi Rastogi finally publicly available. Based upon original findings by my previous graduate student Dr. Sarah Ellinwood ( @SarahE_PhD ). publiclhttps://dx.plos.org/10.1371/journal.ppat.1009712
and here is the link that works: dx.plos.org/10.1371/journa…
So thrilled to share our team effort to understand the properties of T cells that recognize #neoantigens in the tumor microenvironment #TME at single cell resolution published in @Nature! #TeamScience with @jihk99 @SmithImmunology @dpardol1. nature.com/articles/s4158…
The first ever @RockLabTB research paper is out in @CellCellPress cell.com/cell/fulltext/… A herculean effort co-led by PhD student Barbara Bosch & bioinformatician Michael A. DeJesus. Here’s a summary of our quest to identify the (genetic) Achilles’ heel(s) of M. #tuberculosis.
Mentors, don’t neglect scientific trainees. Treat them as you’d like to be treated sciencemag.org/careers/2021/0…
The Vilcek Foundation welcomes @HeranDarwin has been to the board. “As a member of the board, Heran’s insights will enrich our prizes, programs. and operations," said Vilcek Foundation President Rick Kinsel. vilcek.org/news/heran-dar… #WomeninSTEM #STEMwomen #Philanthropy
Clément Raynaud is now Doctor Raynaud!!. Very nice presentation! 👏 Clément. Thanks to the committee members for evaluation of his work.
Role of LmeA, a Mycobacterial Periplasmic Protein, in Maintaining the Mannosyltransferase MptA and Its Product Lipomannan under Stress msphere.asm.org/content/5/6/e0… Just published! Yay!
Congrats and thank you to our ID colleagues who have led the charge in fighting COVID-19. #IDWeek2020 and #chasingthesun will showcase the SCIENCE that saves lives. @SHEA_Epi @ClareRock1
Working on a manuscript this morning with no meetings in my calendar, I have realised how much I love writing and the time it gives you to explore and think.
#OnThisDay in 1943, graduate student Albert Schatz isolated streptomycin, the first antibiotic found to treat #TB. Find out more about #tuberculosis in our blog post: microb.io/2IGArnr
The best part of my job is the opportunity to assemble amazing teams to work on some of the world’s most challenging biomedical problems. Check out our latest: news.mit.edu/2020/gaussian-…
We love M. tuberculosis MmpL3 and are continuing to explore it both as a drug target and a mechanism of resistance to novel compounds. Also, this was very quick from acceptance to publication, which was a very good experience. msphere.asm.org/content/5/5/e0…