Samuel Widodo @samuelsw
PhD student @unimelb | Mantamadiotis Lab | Brain tumour microenvironment research; macrophage enthusiast | 🇮🇩🇦🇺 Joined January 2010-
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Back at #lornecancer! Highlight was @michelle_monje 's neuro-glioma talk! photo with fabulous researchers @samuelsw @dinevska_marija @BerrocalRubio checkout SW's poster #215 'Transcriptional reprogramming of tumour associated macrophages in glioblastoma'
Congratulations to @dinevska_marija & colleagues, for being awarded the MBSANZ 2023 ‘Paper of the Year’ in the Early Career Researchers Category. You can read the paper here: sciencedirect.com/science/articl… #extracellularmatrix #matrixbiology #ECM
Our review on how a master transcriptional regulator of brain function & immunity, CREB, is co-opted to support brain tumour development @UniMelbMDHS @TheDohertyInst @drlaura_cook @dinevska_marija @samuelsw #glioblastoma #brain #TME #immunosuppression doi.org/10.1016/j.bbi.…
If you're interested in the spatial analysis of spheroids/organoids/tumorspheres, check out our new published protocol chapter in Neurobiology Methods & Protocols. link.springer.com/protocol/10.10… @Theo_BrainC_lab @samuelsw We thank editor @DworkinSeb
#Glioblastoma initiation visualized using @AkoyaBio Phenocycler 2.0 showing transition of neural #stemcells into #GBM cells. H&E image published in doi: 10.1093/neuonc/noy068. Using multiplex-IHC we can now see cell-molecular changes occurring during GBM development @UniMelbMDHS
Incredible depth & clarity of mouse brain & mouse brain tumor tissue using @AkoyaBio Phenocycler-Fusion 2.0 combining barcoded antibody labeling & AI-assisted cell-immune-tissue phenotyping. CHECK POSTER @ #sfn2023 #research @UniMelbMDHS #GBM #glioblastoma #neuroscience #cancer
Today at the Melbourne Brain Symposium, presenting our multi-omics approach to characterize the molecular diversity of the myeloid lineage. @mincle & the Well's lab are working towards identifying novel myeloid transcripts and proteins that explain macrophage diversity (1/2).
A great conference with a diverse range of speakers with the same focus of tackling cancer. I felt honoured to be given the opportunity to share my PhD work, thanks to the organisers @VCCCAlliance #VCCCA23
A great conference with a diverse range of speakers with the same focus of tackling cancer. I felt honoured to be given the opportunity to share my PhD work, thanks to the organisers @VCCCAlliance #VCCCA23
@UniMelbMDHS PhD graduate researchers @samuelsw & @dinevska_marija @ #EACR2023 Torino, presenting their fabulous discovery research: mapping cancer cell & immune cell activity, & ECM, in #glioblastoma #GBM & #brainmet #TME using @AkoyaBio #spatialbiology #pathology 4 #BrainCancer
@UniMelbMDHS PhD graduate researchers @samuelsw & @dinevska_marija @ #EACR2023 Torino, presenting their fabulous discovery research: mapping cancer cell & immune cell activity, & ECM, in #glioblastoma #GBM & #brainmet #TME using @AkoyaBio #spatialbiology #pathology 4 #BrainCancer
First time sharing my research live, on-air on @einstein_agogo @3RRRFM. It was a fantastic experience, thanks to @DrShaneRRR. It was also great meeting 20 other superb science communicators. #20PhDsin20mins
First time sharing my research live, on-air on @einstein_agogo @3RRRFM. It was a fantastic experience, thanks to @DrShaneRRR. It was also great meeting 20 other superb science communicators. #20PhDsin20mins
Excited to be sharing my PhD work on @einstein_agogo @3RRRFM this weekend. I will be talking about tumour-associated macrophages in brain tumours! #20PhDs20mins
Excited to be sharing my PhD work on @einstein_agogo @3RRRFM this weekend. I will be talking about tumour-associated macrophages in brain tumours! #20PhDs20mins
What a champion! Great talk @dinevska_marija and congratulations! It has been amazing working alongside you.
What a champion! Great talk @dinevska_marija and congratulations! It has been amazing working alongside you.
Congratulations to @dinevska_marija & colleagues on being awarded the MBSANZ Paper of the Month (March) in the ECR category for their work analysing the spatial matrisome in metastatic brain tumours | sciencedirect.com/science/articl… | @Theo_BrainC_lab @micpapanicolaou @samuelsw @TCox_Lab
Great paper that investigates & maps the metastatic #braintumor microenvironment using #spatialbiology tech including the #PhenoImager solution. bit.ly/405eXUc 👏 Congrats to all involved! @samuelsw @Theo_BrainC_lab @TCox_Lab #spatialanalysis #glioblastoma #multiplex
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Excited to share our new paper in @CellCellPress on spatial organization in glioblastoma authors.elsevier.com/c/1izT9L7PXqQI9. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/
Very pleased to announce our cooperative nature article with the Krönke lab about glucocorticoid effects in immune metabolism, thanks to Jean-Philipp, Max, Maria, Ulrich, Eicke, Jörg, Georg, Gerhard and many more excellent collaborators! Check out at nature.com/articles/s4158…
A great few days here at the EACR Tumour Ecosystems conference in Bergamo 🇮🇹 @EACRnews!! A fascinating range of talks covering all facets of the tumour microenvironment finished off with a captivating EMBO keynote from @ClareIsacke
Honoured to be awarded the Student Poster Presentation by @illumina at the #LorneGenome24. After 3 years of attending the Lorne conferences unfailingly, this feels like a major recognition of the work I am carrying out in my PhD. Thanks everyone who supported me to make it here!
Back at #lornecancer! Highlight was @michelle_monje 's neuro-glioma talk! photo with fabulous researchers @samuelsw @dinevska_marija @BerrocalRubio checkout SW's poster #215 'Transcriptional reprogramming of tumour associated macrophages in glioblastoma'
Mouse brain pre (L) & post clearing (R) + spatial mIHC - we'll be able to precisely map key tumor components: @samuelsw @dinevska_marija RaihanahP Keast Lab. Thanks for pioneering work - ClearT2 CLARITY iDISCO et al., especially work by @erturklab #GBM #braintumors @UniMelbMDHS
Thank you @MatrixBioANZ for recognising our work where we discovered that immune cells are trapped in the ECM of metastatic brain tumours. It has been great working alongside @Theo_BrainC_lab & @samuelsw!
Congratulations to @dinevska_marija & colleagues, for being awarded the MBSANZ 2023 ‘Paper of the Year’ in the Early Career Researchers Category. You can read the paper here: sciencedirect.com/science/articl… #extracellularmatrix #matrixbiology #ECM
Congratulations to @dinevska_marija & colleagues, for being awarded the MBSANZ 2023 ‘Paper of the Year’ in the Early Career Researchers Category. You can read the paper here: sciencedirect.com/science/articl… #extracellularmatrix #matrixbiology #ECM
So happy to see our research on brain metastasis and the tumor vasculature finally out in Cancer Cell! 😍🍾 Thanks to @Johanna_A_Joyce for your mentorship, to all the co-authors for your contributions and to @EMBO and @HFSP for funding my postdoctoral stage 🙂
Thrilled our study on #brain #metastasis #vasculature is out @Cancer_Cell!! Integrated analyses of human & mouse tumors revealed immune-regulatory pathways in endothelial & mural cells for therapeutic blockade Led by the amazing @BejaranoLeire 🤩 cell.com/cancer-cell/fu… 1/ 🧵
2023: @dinevska_marija's PhD completion🎉; papers showed #ECM traps immune cells in #GBM & #BrainMets: thnx @samuelsw, Dr Stylli & the Matrix: @TCox_Lab! Looking forward to 2024 & leveraging these discoveries to enhance brain cancer therapy @UniMelbMDHS @TheDohertyInst @AkoyaBio
1⃣We defined the metabolome of M-CSF- vs GM-CSF-differentiated human macrophages. 2⃣We discovered adenine to be more abundant in M-CSF macrophages. 3⃣Adenine suppressed inflammation and elicited metabolic quiescence Mechanism to be uncovered... ➡️sciencedirect.com/science/articl…
Best Christmas gift!!😍🎉 Thanks to @Johanna_A_Joyce and all the authors involved!🍾🥳
Delighted to receive this early Christmas gift! 🎁🎅🏼🎄 "We are happy to accept your manuscript for publication.. " Congratulations to all authors - and especially first author @BejaranoLeire, a brilliant postdoc 🤩 @Joycelab!! 🍾🥂🎊🥳
Overjoyed to have graduated last week! Many thanks to @Theo_BrainC_lab, Stan Stylli & @samuelsw for your support throughout the years. @UniMelbMDHS
Our review on how a master transcriptional regulator of brain function & immunity, CREB, is co-opted to support brain tumour development @UniMelbMDHS @TheDohertyInst @drlaura_cook @dinevska_marija @samuelsw #glioblastoma #brain #TME #immunosuppression doi.org/10.1016/j.bbi.…
Front covert art! The 2nd lab paper this month! Great way to finish the year! Well done @dinevska_marija @samuelsw @UniMelbMDHS & thanks @DworkinSeb for putting together this great issue!
If you're interested in the spatial analysis of spheroids/organoids/tumorspheres, check out our new published protocol chapter in Neurobiology Methods & Protocols. link.springer.com/protocol/10.10… @Theo_BrainC_lab @samuelsw We thank editor @DworkinSeb
If you're interested in the spatial analysis of spheroids/organoids/tumorspheres, check out our new published protocol chapter in Neurobiology Methods & Protocols. link.springer.com/protocol/10.10… @Theo_BrainC_lab @samuelsw We thank editor @DworkinSeb
Packed house at the oration and celebration for Prof Rob Ramsay @PeterMacRes @PeterMacCC . 20 years ago Rob convinced me to convert my Masters to a PhD, he is an incredible mentor, wishing him well!
Indeed! A legend in Parkville & beyond! Prof Rob Ramsay is a fantastic mentor, friend & colleague!
Packed house at the oration and celebration for Prof Rob Ramsay @PeterMacRes @PeterMacCC . 20 years ago Rob convinced me to convert my Masters to a PhD, he is an incredible mentor, wishing him well!
#Glioblastoma initiation visualized using @AkoyaBio Phenocycler 2.0 showing transition of neural #stemcells into #GBM cells. H&E image published in doi: 10.1093/neuonc/noy068. Using multiplex-IHC we can now see cell-molecular changes occurring during GBM development @UniMelbMDHS
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis nature.com/articles/s4155…
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