Müschen Lab @MuschenLab
B-cell dynamics, oncogenic signaling in B-cell malignancies @YaleUniversity. Since January 2026 @muschenlab.bsky.social medicine.yale.edu/profile/markus… New Haven, CT Joined January 2021-
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Müschen Lab retweeted
A signaling loop centering on the protein CD25 sustains the growth of acute leukemias such as #AML and #B-ALL by fine-tuning the activity of oncogenic tyrosine kinases, according to a new study. @MuschenLab @Yale scim.ag/4rMXddQ
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Yale Study Identifies a New Class of Drug Targets for Aggressive Leukemia m.yale.edu/dfyw
On this week's cover of Science Signaling. Congratulations to Ruifeng Sun and Jaewoong Lee, who led this effort! Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia | Science Signaling science.org/eprint/ZZKJPHH…
EACR - Overactivation of Oncogenic Signalling as a Potential Cancer Treatment Strategy - ecancer ecancer.org/en/conference/…
Beta-catenin promotes cancer cell growth but B-cell leukemia cells, unexpectedly, depend on its efficient degradation. Our paper out today in @NatureCancer, shows how this dependency could be leveraged for the benefit of patients with B-ALL.👇 nature.com/articles/s4301…
👇In a few weeks, the Samir Zaidi Lab will open at Yale. Exciting and important science and a generous and supportive mentor - phenomenal opportunity for future graduate students and postdocs with an interest in lineage plasticity and drug resistance in cancer.
Fifteen years ago, my wife, Salimah, and I met as graduate students at @Yale in New Haven. Now, in a full-circle moment, I’m thrilled to share that I’ll be joining the @YaleCancer and @ynhhealth to launch my independent lab in March 2025! @samirzaidi I’ll be based in the Center
Welcome back to Yale, Samir. So glad to have you joining us!
Fifteen years ago, my wife, Salimah, and I met as graduate students at @Yale in New Haven. Now, in a full-circle moment, I’m thrilled to share that I’ll be joining the @YaleCancer and @ynhhealth to launch my independent lab in March 2025! @samirzaidi I’ll be based in the Center
Müschen Lab retweeted
New research presented at #ASH24 from the @MuschenLab by @RuifengSun2 shows the previously unrecognized role of PKCδ and CD25 in to control BCR signaling in Mature B-Cell #Lymphoma. @YaleMed @OncoAlert @YaleHematology ash.confex.com/ash/2024/webpr…
Müschen Lab retweeted
.@RuifengSun2 presents research @MuschenLab showing CD25 as a regulator of the B pathway and suggesting it as a new therapeutic target for acute lymphoblastic leukemia #ALL at #ASH24. @YaleHematology @OncoAlert @YaleMed @YaleIBIO ash.confex.com/ash/2024/webpr…
Müschen Lab retweeted
Zhangliang Cheng @MuschenLab presents on the 3 stages of B Cells and oscillations between MYC and BCL6 dependent states in B Cell #lymphoma. #ASH24 @YaleMed @SmilowCancer
Congratulations, both of you!
We all have our scientific role models. I’m so lucky that mine was my own mom. 1st-generation & running a lab while raising two boys, she overcame many barriers, to say the least. After 45 years of discoveries @MIT, I hope you enjoy retirement! news.mit.edu/2024/jane-jane…
Müschen Lab retweeted
Leo Meriranta @Merijellona is defending his PhD thesis “molecular cross-section of high/risk #DLBCL” today. It is an honor to chair and enjoyable to listen high level scientific discussion lead by Dr Dan Hodson. Thank you Dan, well done Leo!
Wonderful to be hosting Michael Reth @theNASciences , who discovered the ITAM and pioneer in immune receptor signaling. Thank you for an inspirational seminar @YaleIBIO and private brainstorming session over breakfast.
Müschen Lab retweeted
The ‘China Initiative’ failed US research and national security. Don’t bring it back. thehill.com/opinion/nation…
Müschen Lab retweeted
Excited our final version of @tineisadora's work on targeted protein relocalization is out today @Nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH @StanfordUChem nature.com/articles/s4158…
@KevinWNg Very cute picture of Clovis. I admire how he is always happy and with shining fur (I think biomarker of dog happiness), not a small feat in Manhattan. Our basset hound passed away a few years ago, hoping to not be dogless for much longer.
@LindaCPhD This is what I learned from Christian: small grants add up and we should appreciate them. I am glad to see that both of us are following Christian's philosophy!
Congratulations, Linda!
Received an NOA for a small foundation grant 💰 today. Feeling very excited and grateful. 😊 #NewPI #AcademicChatter #AcademicTwitter
Congratulations, Uli, taking PU.1 research to a whole new level.
Very happy and proud to see this study on PU.1 transcription factor "redistribution" and its mechanistic implications out in @NatureGenet today. Huge congrats to lead author @SamuelJohnTayl1! (recruiters watch out: Sam is on the faculty job market now...!). A big thank you also
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