MedChemExpress @MedChemExpress
A leading global provider of scientific chemicals and bioactive compounds. #Inhibitor, #Agonist, #Protein, #Kit, #Dye, #PROTAC, #ADC, #Screeing Services. medchemexpress.com United States Joined January 2014-
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#Bardoxolone is a #Nrf-2 Activator for Chronic #Kidney #Disease Research #Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator and can be used in chronic kidney disease research. For more detailed information:medchemexpress.com/Bardoxolone.ht… immune-system-research.com/2024/03/08/bar…
🍻 #Danoprevir is a #Protease Inhibitor for #Hepatitis C #Virus #Infection and #COVID19 Research 👉 For more detailed information:medchemexpress.com/Danoprevir.html immune-system-research.com/2024/02/14/dan…
🍻 Published in #Cellular and #Molecular Life #Sciences! Related Product Recommendation: #Calreticulin Antibody. It can be used for #WB, #ICC, #IHC-P, #FC, #IP assays with tag free. 👉 medchemexpress.com/antibody/calre… 👉 For more detailed information: onlinelibrary.wiley.com/doi/epdf/10.10…
🍻 #BTX6654 and #BTX7312, cereblon-based bifunctional #SOS1 degraders. 👉 MCE Raleted Products: medchemexpress.com/btx-6654.html medchemexpress.com/btx-7312.html 👉 For more detailed information: pubmed.ncbi.nlm.nih.gov/38224565/
🍻 #Darovasertib is an #Orally Active #PKC Inhibitor for #Uveal #Melanoma Research The #FDA granted Darovasertib for the treatment of uveal melanoma in May 2022. For more detailed information: medchemexpress.com/LXS196.html cancer-research-network.com/2024/02/14/dar…
🥳🥳Wow~ Our customers published a paper in #Nature!!! The study developed an antibody-drug conjugate (#ADC) that can kill #TRBC1+ cancer cells in vitro and cure human T-cell #cancers in mouse models. pubmed.ncbi.nlm.nih.gov/38538786/
🎈 #Umbralisib is an #Orally Active Dual #PI3Kδ/CK1ε Inhibitor for #Haematological #Malignancies Reseach 👉 For more detailed information: medchemexpress.com/TGR-1202.html 👉 cancer-research-network.com/2023/12/19/umb…
✨#Hematology & #Oncology: Based on #virtual #screening, this study obtained the #GPD1 allosteric activator Wedelolactone from the #MCE Bioactive Compound Library and demonstrated its ability to inhibit bladder tumor growth both in #vitro and in #vivo. 👉 medchemexpress.com/virtual-screen…
🤩🤩Wow! Our customers published a paper in #Signal Transduct Target Ther~ This paper provided novel insights into the pathogenic role of #SARS-CoV-2 E protein in #airway #epithelial damage and the ongoing airway #inflammation during SARS-CoV-2 #infection. pubmed.ncbi.nlm.nih.gov/38528022/
#Danoprevir is a #Protease Inhibitor for #Hepatitis C #Virus #Infection and #COVID-19 Research For more detailed information: medchemexpress.com/Danoprevir.html immune-system-research.com/2024/02/14/dan…
Published in Cell: revealed that EPS masked the ability of lung TRPV1+ sensory neurons to recognize LPS through TLR4 after bacterial infection in the lungs, ultimately altering post-infection disease symptoms. pubmed.ncbi.nlm.nih.gov/38518773/ #Cell #MCE #Infection #EPS #LPS
🍻 Published in Signal Transduction and Targeted Therapy: A novel #QPCTL inhibitor, #QP5038 , showed superior inhibitory effects on CD47 pyroglutamation. 👉 For more detailed information: nature.com/articles/s4139… 👉 MCE Raleted Products: medchemexpress.com/qp5038.html
🥳🥳Wow! Our customers published a paper in #Science~ This study showed that #ABCB19, a member of the ATP-binding cassette (#ABC) transporter superfamily, functioned as a #brassinosteroid exporter and revealed its #mechanism. pubmed.ncbi.nlm.nih.gov/38513023/
#HIV (Human immunodeficiency #virus) is a lentivirus (a subgroup of retrovirus). And it causes the acquired immunodeficiency syndrome (#AIDS). #Etravirine is a Non-nucleoside Reverse Transcriptase #Inhibitor for #HIV Research medchemexpress.com/etravirine.html 👉 immune-system-research.com/2024/02/01/etr…
🤩🤩Wow~Our customers published a paper in Nature again!!! This study indicated that macrophages use Pol II pause/release as a mechanism to rapidly alter their transcriptional programs for efficient processing of the ingested apoptotic corpses. pubmed.ncbi.nlm.nih.gov/38480883/
🔔 #MCE provides #Metabolism/ #Protease Compound Library (HY-L012, 4000+ compunds), aiming to provide some help for the HTS of metabolism-related drugs. 👉 MCE Raleted Products: medchemexpress.com/screening/Meta… medchemexpress.com/screening/meta… medchemexpress.com/screening/prot…
📣 #Peficitinib is an orally active #JAK #inhibitor for #rheumatoid #arthritis research 👉 For more detailed information: medchemexpress.com/Peficitinib.ht… 👉 immune-system-research.com/2024/01/31/pef…
📣 #Peficitinib is an orally active #JAK #inhibitor for #rheumatoid #arthritis research 👉 For more detailed information: medchemexpress.com/Peficitinib.ht… 👉 immune-system-research.com/2024/01/31/pef…
🥳🥳Congratulations! our customers published a paper in #Cell~ This article reveals that cells enrich damaged #RNA and activate dsRNA-mediated #immune signaling pathways through membrane-less #DHX9 stress granules. pubmed.ncbi.nlm.nih.gov/38503283/
Aitor Picos Martínez @iTorPicos
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1K Followers 3K FollowingEveryone loves chemobiology like the mascot of @MedChemExpress 🐘 #ChemBio2024
@Novartis - kudos for scientific transparency and sharing the structure of your YAP/TEAD interface inhibitor - IAG933. @medkoobio @selleckchem @MedChemExpress - a really useful tool compound to study the Hippo pathway bioworld.com/articles/69637…
Published in Cell: revealed that EPS masked the ability of lung TRPV1+ sensory neurons to recognize LPS through TLR4 after bacterial infection in the lungs, ultimately altering post-infection disease symptoms. pubmed.ncbi.nlm.nih.gov/38518773/ #Cell #MCE #Infection #EPS #LPS
#Danoprevir is a #Protease Inhibitor for #Hepatitis C #Virus #Infection and #COVID-19 Research For more detailed information: medchemexpress.com/Danoprevir.html immune-system-research.com/2024/02/14/dan…
🤩🤩Wow! Our customers published a paper in #Signal Transduct Target Ther~ This paper provided novel insights into the pathogenic role of #SARS-CoV-2 E protein in #airway #epithelial damage and the ongoing airway #inflammation during SARS-CoV-2 #infection. pubmed.ncbi.nlm.nih.gov/38528022/
🥳🥳Wow! Our customers published a paper in #Science~ This study showed that #ABCB19, a member of the ATP-binding cassette (#ABC) transporter superfamily, functioned as a #brassinosteroid exporter and revealed its #mechanism. pubmed.ncbi.nlm.nih.gov/38513023/
📣 #Peficitinib is an orally active #JAK #inhibitor for #rheumatoid #arthritis research 👉 For more detailed information: medchemexpress.com/Peficitinib.ht… 👉 immune-system-research.com/2024/01/31/pef…
📣 #Peficitinib is an orally active #JAK #inhibitor for #rheumatoid #arthritis research 👉 For more detailed information: medchemexpress.com/Peficitinib.ht… 👉 immune-system-research.com/2024/01/31/pef…
🥳🥳Congratulations! our customers published a paper in #Cell~ This article reveals that cells enrich damaged #RNA and activate dsRNA-mediated #immune signaling pathways through membrane-less #DHX9 stress granules. pubmed.ncbi.nlm.nih.gov/38503283/
👉 Related Product Recommendation: #DAPI dihydrochloride: DAPI dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to #DNA. 👉 For more detailed information: nature.com/articles/s4146… 👉 medchemexpress.com/DAPI_dihydroch…
🤩🤩Wow! our customers published a paper in #cancerCell~ This study revealed the key molecular #mechanism that promotes the formation of vascular #tumor thrombus in early #bladder #cancer and provided new #targets for bladder cancer. pubmed.ncbi.nlm.nih.gov/38428409/
🥳Wow~our customers published a paper in #CellResearch! This study confirmed that #cancer cells trigger brain activation by releasing two cytokines, LIF and Gal3 , and blocking #LIF or #Gal3 signaling abolishes the brain response and inhibits tumor growth. pubmed.ncbi.nlm.nih.gov/38467743/
🔔 Published in AACR: A selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors. 👉 For more detailed information: aacrjournals.org/cancerdiscover… 👉 MCE Related Prouduct:medchemexpress.com/inx-315.html
📢 Published in Cell Discovery: 🔔 Direct binding assay: The desired proteins were eluted from the beads with 200 ng/μL FLAG peptide (MCE, HY-P0319). 👉 MCE Related Prouduct:medchemexpress.com/3X_FLAG_peptid… 👉 For more detailed information: nature.com/articles/s4142…
🍻 #Tamibarotene is an Orally Active #RARα Agonist for #AML and Other #Cancers Researc 👉 For more detailed information:cancer-research-network.com/2024/01/19/tam…
🥳🥳Wow! our customers published a paper in #Immunity~ This study revealed how non-neuronal brain cells coordinate the function of #neurons in healthy and pathological states, and provided a potential new #target for the treatment of #anxiety disorders. pubmed.ncbi.nlm.nih.gov/37576060
🍻 #Efbemalenograstim alfa is a Recombinant Fusion #Protein for #Neutropenia Research It activates #STAT3, and stimulates the proliferation of 32D-GCSFR and M-NSF60 #cell lines. 👉 For more detailed information: medchemexpress.com/efbemalenogras… 👉 immune-system-research.com/2023/12/01/efb…
😎 🍻 Gambogic amide (GA-amide) exhibits the ability to effectively penetrate the BBB and displays a notable enrichment within the tumor region. 👉 #MCE Related Product: medchemexpress.com/gambogic-amide… 👉 For more detailed information: pubmed.ncbi.nlm.nih.gov/37935665/
🍻 Published in Science: PtpB dephosphorylates host plasma membrane phosphoinositides upon activation by ubiquitin to inhibit pyroptosis. 👉 Related Product: IL-18BP Protein, Mouse (HEK293, His): lnkd.in/gjXj5_Th 👉 For more detailed information: lnkd.in/gYn8CExV