Bryan Copits @BryanCopits
Pain neuroscientist and electrophysiologist. Trying to understand how neurons are wired into circuits. New PI at WashU in St. Louis https://t.co/TPrJaftjlu sites.wustl.edu/copitslab/ Joined October 2017-
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🚨 Our department is growing and we are hiring ! We have a tenure track position open to join the amazing environement at @PharmPhysSLU and @SLU_ITN! We are looking forward to reinforce our pain group. Don't hesitate to reach out with questions.
1/3 It's important to note that most mApple-based biosensors exhibit blue light-illuminated photoactivation, and proper controls (e.g. mutant-sensor or biosensor-only controls) should be included in combined use with blue-light optogenetics or dual-color recording.
1/3 It's important to note that most mApple-based biosensors exhibit blue light-illuminated photoactivation, and proper controls (e.g. mutant-sensor or biosensor-only controls) should be included in combined use with blue-light optogenetics or dual-color recording.
This report is indeed short. You have time to read it. Many of us have some power to help change it. So let’s do it.
This report is indeed short. You have time to read it. Many of us have some power to help change it. So let’s do it.
a little human spinal cord physiology to brighten your feed. Recording by @JunNanLi5, assist by @BryanCopits and outstanding tissue recovery team (it takes a village) this afternoon. Thanks to @NIHendaddiction for funding this exciting work.
Some PdCO variants are now available as AAV2/9 from: vcf.charite.de/en/catalog/cat… [CamKII(0.4)/ hSyn/ hSyn-DIO] All plasmids still here @Addgene: addgene.org/browse/article… AAV2/5 hSyn-SIO: vvf.ethz.ch (v816)
📜 Preprint alert! Our latest work on #ephys analyses of human DRG & hiPSC-derived sensory neurons is now online @biorxivpreprint Thanks to the incredible team that made this possible! We hope this will be a useful resource to #pain researchers biorxiv.org/content/10.110…
We're really excited about this project! To piggyback off of @NeuroTejeda's tweet, we're also hiring. Please reach out if you're interested in protein engineering, slice electrophysiology, and/or high throughout screening.
We're really excited about this project! To piggyback off of @NeuroTejeda's tweet, we're also hiring. Please reach out if you're interested in protein engineering, slice electrophysiology, and/or high throughout screening.
If you’re collaborating with Israeli PIs, think about whether you could invite one of their international trainees for a short stay so that they can get some work done while they are unable to return to their home lab.
If you’re collaborating with Israeli PIs, think about whether you could invite one of their international trainees for a short stay so that they can get some work done while they are unable to return to their home lab.
🎉Today our paper on single vector CRISPR/Cas9 gene editing 🧠🧬 and marker gene expression is available on @biorxivpreprint! This is my 1st lead author paper in @BryanCopits lab, and was a collaboration with @Meaghan_Creed's lab! Check out the tweetorial! biorxiv.org/content/10.110…
Featured in August issue: @JudyYoo and team (@UCincyMedicine) characterize the impact of early life iron deficiency on nociception development. - Perinatal iron deficiency exacerbates post-surgical pain in adulthood Full access for 30 days: jpain.org/article/S1526-…
Congrats to co-first authors @shamsChronicles, @MengyiXu4 and all our @NIHendaddiction U19 collaborators @UTDPainLab @robgereau et al. for building such a useful resource - harmonized.painseq.com - for studying sensory ganglia cell types across species! x.com/shamschronicle…
Excited to share my first postdoc study, titled “Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia”. biorxiv.org/content/10.110… 1/n
Amazing work from @willrenthal and his team with contributions from the other U19 PRECISION Pain Centers (@UTDPainCenter and @WashUanesthesia) funded by @NIH @NIHPainResearch @NINDSfunding. Thanks to @dianatavf @JulietMwirigi and @ish1789 for their contribution from our lab
Amazing work from @willrenthal and his team with contributions from the other U19 PRECISION Pain Centers (@UTDPainCenter and @WashUanesthesia) funded by @NIH @NIHPainResearch @NINDSfunding. Thanks to @dianatavf @JulietMwirigi and @ish1789 for their contribution from our lab
New preprint from the lab! We conducted a systematic analysis of bistable optoGPCRs for presynaptic inhibition, which led to the characterization of PdCO: a bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits biorxiv.org/content/10.110…
🚨!#Optogenetic preprint alert!🚨 Check out PdCO: Light-controlled inhibition of synaptic transmission via the inhibitory #GPCR pathway. #Optogenetics #neuroscience Link: biorxiv.org/content/10.110…
Day 2 @NAPainSchool: Great presentation @JudyYoo! Her research focuses on how early life injury could impact the development of spinal astrocytes. #NAPainSchool
🚨Paper Alert🚨 Very happy to share my first postdoctoral work from the Gereau Lab @robgereau . This collaborative work, co-led by former member Lisa McIlvried, show that homeostatic plasticity is engaged in mouse and human DRG neurons. biorxiv.org/content/10.110…
We’re hiring! Projects combine genomics, in vivo ephys and synaptic physiology to understand how plasticity in basal ganglia circuits give rise to maladaptive decision making- with a focus on models of substance use disorder and chronic pain! (1/n)
Very excited to share the first paper from the lab on bioRxiv!😊Here, we establish that ketamine rescues stress-induced anhedonia via cell-type-specific adaptations as well as information integration in the NAc via discrete excitatory synapses. biorxiv.org/content/10.110…
Ted Price of the Duss.. @UTDPainLab
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720 Followers 672 FollowingCeline Santiago @celinesan
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242 Followers 355 Following Postdoc at University of Michigan studying psychedelic neurophysiologyLarissa Staurengo-Fer.. @larissasferrari
179 Followers 534 Following Research fellow at @harvardmed, studying pain | Chiu lab @isaacchiulabFelicitas Huber @feli_huber
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123 Followers 588 Following interested in studying neuron-glia interaction in learning & memory, chronic pain, and aging related diseasesAngelika Lampert @LampertLabRWTH
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506 Followers 525 Following @AvHStiftung alum @MDC_Berlin, PhD @Gates_Cambridge @Cambridge_Uni. neuroscience, pain, educational outreachBrandon Ng @kelticwai17
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182 Followers 325 Following Post-doc in David Ginty's lab, Harvard Medical SchoolA. Mortensen lab ❄�.. @Amortensenlab
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8 Followers 23 Following Research Scholar working on Bioimaging and Data Analysis. Areas of interest: confocal microscopy, flow cytometry, mathematical modeling, statistics.Lindsay🧠 @neuro_melody
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292 Followers 517 Following Postdoc @UChiChemistry | PhD @MBU_IISc | Fascinated about ion channels and exchangers! #neuroscience #electrophysiology #patchclampSema Quadir, PhD @superrsema
3K Followers 3K Following Professional Rodent Bartender. Postdoc @NUFeinbergMed. Prev @BCAS_UNC, @PharmBU, @MCDBUCSB and @UCSBPsych. She/her/hersShams @shamsChronicles
115 Followers 142 Following Postdoc at the Renthal Lab | Brigham and Women’s Hospital | Harvard Medical School | Maybe the real science were the friends we made along the wayMelissa Lenert, PhD @meleliza721
217 Followers 759 Following @lab_nib at UT-Dallas. NIH/NINDS D-SPAN Scholar. Studying neuroimmune and endocrine mechanisms in pain and physiology. Dog mom to Luna.I had a blast presenting our labs recent work on proprioception at @NIH today! First time visiting. Thanks so much for the invite @Alex_Chesler! Many productive conversations and it was also super fun to hang out with @YarCarLab and @robgereau yesterday before my talk!
Just heard an amazingly inspiring talk from Edward Mowery about his lived experience with pain and his incredible response to deep brain stimulation treatment from @PrasadShirvalka. Neuroscience in action! @NIHPainResearch @NIHendaddiction
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An exemplary presentation by @doctheagrif yesterday! Her recent findings on mammalian proprioception were highlighted to a captivated audience at her #PMB in-house seminar! 🔬🙌🏾🌟 #ScientistSketch
👏A 👏C 👏C 👏E 👏P 👏T 👏E 👏D 👏!! 🥳🥳🥳🥳🥳 So many thanks to everyone involved!
Thrilled to announce that I have accepted a TT faculty offer at Vanderbilt University in the Dept. of Pharmacology @VandyPharm and Vanderbilt Brain Institute @VanderbiltBrain, starting in September 2024!! 🥳🥳 We will study mechanisms of somatosensory circuit assembly for touch…
Excited to co-host @robgereau with @LaiL4b for the Neuroscience seminar series here @UTSWNeurosci @UTSWBrain next week!
Join us for a #Neuroscience Seminar on Jan 23. Dr. Robert Gereau @WUSTLmed will present “Implantable systems for the study and treatment of pain, substance use disorder and overdose.” @robgereau anesthesiology.wustl.edu/people/robert-…
A few months and experiments later, the lab’s first paper 🎉 Incredibly proud of Carolyn Lorch and the work she led, excited to follow up on these studies, and grateful for a constructive peer review process that made the paper better. cell.com/cell-reports/f…
Excited to share the first preprint from the lab, led by the fear- and Twitter-less Carolyn Lorch. A very brief tweetorial:
And that is how Katz and I discovered that quantal release of acetylcholine was happening at the neuromuscular synapse. Turbocurare was a thing back then. Alas no more.
Had a fantastic visit with this great department!
This week's research seminar features @KaraLMarshall from @bcmhouston. Details below ⬇️ 📆 Tuesday, Jan. 9 ⏰ 4:00 p.m. 🔬 “Feeling the force: PIEZO ion channels in interoception” 📍 EPNEC Seminar Room A anesthesiology.wustl.edu/events/event/r…
Are you using the red dopamine (DA) sensor RdLight1 in combination with blue light for dual-color optogenetics/photometry? If so, read on... biorxiv.org/content/10.110… 1/n
New paper alert! Our work on the extra-amygdalar panic circuit has been published @NatureNeuro. Congrats to co-first authors @SJ_J_Kang_24 and Jonghyun Kim along with all co-authors involved. nature.com/articles/s4159… 🧵(1/n)
Dark times indeed. But we will do what we’ve always done, persist. Though, we shouldn’t have to. We should be able to just exist.
This was not the only such campaign. The F*deral*st did oppo research on me. Mainstream media largely resisted coverage. But the efforts to take down prominent Black writers, intellectuals and politicos is only going to intensify. We are in for some dark times.
year 1: DONE. god speed to all of the new PIs starting their labs this week. only piece of advice I have: you can’t give 100% to all aspects of the job (or at least I couldn’t without ☠️). embrace that and prioritize your effort accordingly.
My first dorsal root stimulation evoked monosynaptic EPSC and PPR recording from a lamina II spinal interneuron!
Check out @M_Saad_Yousuf great 🧵 on his terrific new work just published in @PNASNews on TMEM97 targeting for pain @utdneuroscience @UTDResearch @BBSutdallas @UT_Dallas
Hi, @M_Saad_Yousuf on the UTD CAPS account tweeting about my new paper (loom.ly/kXfcSH4) out in PNAS. Neuropathic pain affects 10% of the population. Here we establish TMEM97/Sigma2 receptor as a bona fide pain target using a highly specific TMEM97 modulator FEM-1689. 🧵
Hi, @M_Saad_Yousuf on the UTD CAPS account tweeting about my new paper (loom.ly/kXfcSH4) out in PNAS. Neuropathic pain affects 10% of the population. Here we establish TMEM97/Sigma2 receptor as a bona fide pain target using a highly specific TMEM97 modulator FEM-1689. 🧵
This photo perfectly sums up my year: productive, but exhausting. Remember to look after yourself, especially those working in healthcare that see death on a daily basis. It's been an eye-opening experience for me working on this donor project. #happyholidays2023 ✌️
A new review and auspicious start to @lisazfang ‘s post-doc. We review and synthesize contemporary circuit dissection studies of the striatum and pallidum, and highlight open questions wrt molecular and functional specification of these circuits. @WashUanesthesia @WashUPain
A Review on updating the striatal–pallidal wiring diagram from Lisa Z. Fang and Meaghan Creed (@Meaghan_Creed) nature.com/articles/s4159…
forum.painresearcher.net/t/whole-mount-… Nice insights on whole mount DRG staining from Derek Molliver