Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward
Stay up-to-date in Infectious Diseases, Clinical Pharmacist, Antibiotics #IDXposts AKA #IDTwitter T🌟P influencer,@Wiki_Guidelines ,#Interstellar,🌹❤️Misk idstewardship.com/contributors/b… 🌍 Joined October 2010-
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🚫Patients developed neurological signs and symptoms after a median of 4 days with seizures being the most common clinical manifestation. 🚫Despite approximately 70% of the patients presenting with seizures, generalized or diffuse slow waves were the most common EEG finding
🚫Patients developed neurological signs and symptoms after a median of 4 days with seizures being the most common clinical manifestation. 🚫Despite approximately 70% of the patients presenting with seizures, generalized or diffuse slow waves were the most common EEG finding
Happy to see it's finally out! 🔥🔥🔥 @UWIDFellowship
Happy to see it's finally out! 🔥🔥🔥 @UWIDFellowship
A case of persistently positive CSF cultures growing CRAB despite ampicillin-sulbactam and cefiderocol treatment. Cultures cleared after transitioning to sulbactam-durlobactam and meropenem #IDXposts
A case of persistently positive CSF cultures growing CRAB despite ampicillin-sulbactam and cefiderocol treatment. Cultures cleared after transitioning to sulbactam-durlobactam and meropenem #IDXposts
🆕️🔥Systematic review #JAC Posaconazole in paediatric malignancy and haematopoietic stem cell transplant: dosing to achieve therapeutic concentration #IDXposts academic.oup.com/jac/article-ab…
Fascinating, especially given the added difficulty of detecting Bartonella "routinely" à la their quote of "Bartonella does not grow in routine blood cultures" @GlomCon
Fascinating, especially given the added difficulty of detecting Bartonella "routinely" à la their quote of "Bartonella does not grow in routine blood cultures" @GlomCon
🆕️⚡️Association between Causative Pathogen and Occurrence of Infection-Related Glomerulonephritis in Infective Endocarditis Bartonella was very strongly associated with IRGN #IDXposts academic.oup.com/cid/advance-ar…
Surprisingly,a recent pharmacovigilance study of the FDA adverse event reporting system demonstrated that among antibiotics evaluated including many other beta-lactams commonly associated with neurotoxicity eg cefepime& imipenem,ertapenem had by far the highest delirium reporting
Surprisingly,a recent pharmacovigilance study of the FDA adverse event reporting system demonstrated that among antibiotics evaluated including many other beta-lactams commonly associated with neurotoxicity eg cefepime& imipenem,ertapenem had by far the highest delirium reporting
Ertapenem is commonly used for weeks in the outpatient setting, both of which could result in underdiagnoses and delays in discontinuation of the offending antibiotic 💯 #IDXposts #OPAT
A practical guide for using antifungal drugs.
A practical guide for using antifungal drugs.
🆕️🔥Case report Successful treatment of refractory CRAB meningitis with sulbactam-durlobactam & meropenem The case highlights the need to be cognizant of the paradoxical effect that can be observed with BMD testing of CRAB isolates with cefiderocol. academic.oup.com/cid/article/do…
🚨 New Article Alert! 🤓 This is a resource for folks wanting to differentiate #Vowst and #Rebyota as therapies to prevent #Cdiff recurrence. Authored by pharmacy student Natalie Boyer and mentors by Dr. Christina G. O’Connor 🙌 👉 idstewardship.com/comparison-reb… #IDtwitter #TwitteRx…
Kinda surprising! No? 🆕️🔥 cohort study 3GC resistance in Klebsiella spp. or E. coli in community-onset bacteremia sig 🔼 the probability of all-cause bacteremia recurrence within 1 year, whereas identification of MRSA does not affect risk for recurrence wwwnc.cdc.gov/eid/article/30…
🆕️⚡️Prospective, multi-centre, head-to-head comparison between allergists vs non-allergists in low-risk penicillin allergy delabelling: effectiveness, safety and quality of life (HK-DADI2)⚡️ #IDXposts Cc @TrubianoJason jaci-inpractice.org/article/S2213-…
"A positive follow-up blood culture for MRSA while on seemingly appropriate therapy is a common and ominous development. However, the definition and management of persistent MRSA bacteremia is unstandardized" #IDTwitter
"A positive follow-up blood culture for MRSA while on seemingly appropriate therapy is a common and ominous development. However, the definition and management of persistent MRSA bacteremia is unstandardized" #IDTwitter
In this Opinion Paper, the authors identify the presence of bacteremia for > 1 calendar day as a “worry point” that should trigger an intensive diagnostic evaluation to identify metastatic infection sites #IDTwitter do you agree ?
In this Opinion Paper, the authors identify the presence of bacteremia for > 1 calendar day as a “worry point” that should trigger an intensive diagnostic evaluation to identify metastatic infection sites #IDTwitter do you agree ?
🆕️⚡️⚡️ Retrospective cohort study demonstrates that the performance of Galactomannan test from non-invasive proximal airway samples is comparable or even better than those from serum &distal airway sample in Diagnosis of Invasive Pulmonary Aspergillosis journalofinfection.com/article/S0163-…
Bug Pharmacist 💊�.. @IDstewardship
37K Followers 1K Following I ❤️ bugs & drugs. #Pharmacist #SaveABX 📸: 35K, 📧: 25K, 👍: 22K 🌐: 5M. 🗣Opinions mine. SUBSCRIBE: https://t.co/TcajDzx2ADBrad Spellberg @BradSpellberg
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129 Followers 334 FollowingBug Pharmacist 💊�.. @IDstewardship
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8K Followers 1K Following Infectious diseases, family, friends, science and arts. Working at HUVM, University of Sevilla and IBiS. ESCMID Past President but here only my own opinionsHappy to see it's finally out! 🔥🔥🔥 @UWIDFellowship
Ertapenem-induced neurotoxicity has not been well characterized and is potentially underreported 🆕️🔥 @OFIDJournal Characterizing Ertapenem Neurotoxicity: A Systematic Review and Experience at a Tertiary Medical Center #IDXposts academic.oup.com/ofid/article/d…
Fascinating, especially given the added difficulty of detecting Bartonella "routinely" à la their quote of "Bartonella does not grow in routine blood cultures" @GlomCon
🆕️⚡️Association between Causative Pathogen and Occurrence of Infection-Related Glomerulonephritis in Infective Endocarditis Bartonella was very strongly associated with IRGN #IDXposts academic.oup.com/cid/advance-ar…
The best antibiotic is appendicetomy
🆕️🔥Three-Year Outcomes of Oral Antibiotics vs Intravenous and Oral Antibiotics for Uncomplicated Acute Appendicitis A Secondary Analysis of the APPAC II RCT #IDXposts jamanetwork.com/journals/jamas…
@ABsteward @BradSpellberg @JAMASurgery Regardless of the route of administration, 65% outcome seems insufficient to me. That desire to fix with antibiotics what is solved with the knife. I don't understand.
@ABsteward @BradSpellberg @JAMASurgery We don't usually like quinolones but they are a valid option, but carbapenem for an uncomplicated community infection?
@IndiTrehan @ABsteward Yeah, saw it. But, seriously, 10 vs 14 days? Gee they really went out on a limb didn’t they.
Does anyone routinely perform a TOE/TEE before oral switch when treating IE?🤔 Can we afford to do so in real life (as in the POET trial)? Is it really necessary for patients who are responding to treatment well (to the extent that discharge from hospital can be considered)?
🆕️⚡️The ‘Ten Commandments’ for the 2023 European Society of Cardiology guidelines for the management of endocarditis⚡️ #IDXposts academic.oup.com/eurheartj/adva…
@ABsteward “Repeat TOE is indicated to rule out disease progression before switching therapy.”
A practical guide for using antifungal drugs.
🆕️🔥Fantastic review 🌟 by 🌟s @Russlewis_BO @ProfMBassetti @dwdenning Triazole antifungal drug interactions—practical considerations for excellent prescribing #IDXposts academic.oup.com/jac/article-ab…
@ABsteward Where does come the high amplitude of calcineurin inhibitors DDI with fluconazole? This is a weak CYP3A inhibitor. 🧐
Small Rct on bezlotoxumab+Fecal transplant vs fmt alone in #ibd patients with recurrent #cdiff. Combination therapy had more patients with recurrent cdiff than #fmt alone... (4 patients vs 1 patient) #lessismore
🆕️⚡️⚡️Small multicenter randomized placebo-controlled trial Outcomes After Fecal Microbiota Transplantation in Combination With Bezlotoxumab for Inflammatory Bowel Disease and Recurrent Clostridioides difficile Infection #IDXposts journals.lww.com/ajg/fulltext/9…
Ha! I knew it was a thing. I have seen a couple of patients with wild hallucinations on erta.
Ertapenem-induced neurotoxicity has not been well characterized and is potentially underreported 🆕️🔥 @OFIDJournal Characterizing Ertapenem Neurotoxicity: A Systematic Review and Experience at a Tertiary Medical Center #IDXposts academic.oup.com/ofid/article/d…
@DrToddLee @ABsteward Analogously, for LRTI, patients who have symptoms for longer are more likely to get antibiotics...that do not seem to shorten the duration of cough. x.com/jeffreylinder/…
1/9 Really nice article by Daniel Merenstein, Bruce Barrett, and @markebell confirming that antibiotics do not help for acute bronchitis/LRTI. link.springer.com/article/10.100…
@ABsteward People at higher risk of failure clinically get treated for longer.
@ABsteward But given mechanism of bloodstream infection and the surface area of the colon vs # of ecoli and klebs, it probably makes sense on top of that.
@ABsteward You cannot recur if you are dead. MRSA does that more than esbl e coli.
🚨 New Article Alert! 🤓 This is a resource for folks wanting to differentiate #Vowst and #Rebyota as therapies to prevent #Cdiff recurrence. Authored by pharmacy student Natalie Boyer and mentors by Dr. Christina G. O’Connor 🙌 👉 idstewardship.com/comparison-reb… #IDtwitter #TwitteRx…